{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:16:30Z","timestamp":1787242590758,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Abstract<\/jats:title>\n \n There is mounting evidence that T helper (Th)17 cells and regulatory T cells (Treg) play parts in the pathogenesis of autoimmune disease. Hence, levels of these T\u2010cell subsets in patients with alopecia areata (\n AA<\/jats:styled-content>\n ) merit investigation. Our goal was to assess Th17 and Treg levels in peripheral blood mononuclear cells (\n PBMC<\/jats:styled-content>\n ) and scalp lesions of patients with\n AA<\/jats:styled-content>\n , correlating the findings with clinical characteristics.\n PBMC<\/jats:styled-content>\n of 177 patients with\n AA<\/jats:styled-content>\n (test group) and 42 healthy controls and scalp tissues of 33 patients and 15 healthy controls were collected. Levels of Th17 and Treg subsets were then determined via flow cytometry and immunohistochemical staining, correlating results in test subjects with clinical features of\n AA<\/jats:styled-content>\n . Th17 levels were significantly higher in patients, whereas Treg levels were lower by comparison. Furthermore, Th17 levels in patients with disease of short duration or in the active phase were significantly higher, relative to their respective counterparts. Th17 levels also negatively correlated with disease duration. While Treg levels were higher in severe\n AA<\/jats:styled-content>\n than in mild\n AA<\/jats:styled-content>\n . Results of lesions were parallel to findings of\n PBMC<\/jats:styled-content>\n . Our data indicates an imbalance in the immune state of patients with\n AA<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/1346-8138.12978","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T03:27:12Z","timestamp":1434425232000},"page":"981-988","source":"Crossref","is-referenced-by-count":79,"title":["Imbalance of T\u2010helper 17 and regulatory T cells in patients with alopecia areata"],"prefix":"10.1111","volume":"42","author":[{"given":"Yu\u2010Mei","family":"Han","sequence":"first","affiliation":[{"name":"Department of Dermatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Yu","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of 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