{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:02:25Z","timestamp":1783706545201,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T00:00:00Z","timestamp":1434758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fixed\u2010dose combination adapalene 0.1% and benzoyl peroxide 2.5% gel (A\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content>) has rarely been studied for Asian acne patients, while they have complained of local irritations more often when applying individual components. In this study, we compared A\u2010BPO gel with benzoyl peroxide (<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content>) in terms of efficacy and tolerability in Korean patients first, and assessed the clinical benefit of a dermatological tutorial on application technique in reducing irritations for A\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content>. This study was conducted as a single\u2010blind controlled split\u2010face trial for a 12\u2010week period. Each half facial side of 85 patients was randomly assigned to either A\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content>. Success rate, lesion counts and safety profiles were evaluated (analysis I). During initial assignment, all patients were further randomized to either dermatological tutorial (<jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content>) or non\u2010tutorial (<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>) subgroups depending on the presence of dermatologists' tutorials for application methods to their A\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> sides. Clinical data of the A\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> side was compared between two subgroups (analysis II). As a result, A\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> gel outperformed <jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content>, demonstrating better efficacy in success rates and lesion counts as early as 1\u00a0week. However, A\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> proved significantly less tolerable compared with both <jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> and previous A\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> data from Caucasians. Bioengineering measurements further confirmed clinical data (analysis I). The <jats:styled-content style=\"fixed-case\">DT<\/jats:styled-content> subgroup achieved much better tolerability with comparable therapeutic efficacies compared with the <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content> subgroup (analysis II). In conclusion, A\u2010<jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> demonstrated higher efficacies in acne compared with <jats:styled-content style=\"fixed-case\">BPO<\/jats:styled-content> in Korean patients, while skin irritation levels were notable concurrently. Dermatologists' education for application methods would significantly decrease these side\u2010effects, maintaining superior efficacy levels.<\/jats:p>","DOI":"10.1111\/1346-8138.12979","type":"journal-article","created":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T08:50:35Z","timestamp":1434790235000},"page":"1058-1065","source":"Crossref","is-referenced-by-count":10,"title":["Do tutorials on application method enhance adapalene\u2013benzoyl peroxide combination gel tolerability in the treatment of acne?"],"prefix":"10.1111","volume":"42","author":[{"given":"Hyuck Hoon","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul Korea"},{"name":"Acne and Rosacea Research Laboratory Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul Korea"},{"name":"Acne and Rosacea Research Laboratory Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Yoon","sequence":"additional","affiliation":[{"name":"Acne and Rosacea Research Laboratory Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonguk","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul Korea"},{"name":"Acne and Rosacea Research Laboratory Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Hun","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul Korea"},{"name":"Acne and Rosacea Research Laboratory Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09209.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.006"},{"key":"e_1_2_7_4_1","first-page":"110","article-title":"A North American study of adapalene\u2010benzoyl peroxide combination gel in the treatment of acne","volume":"84","author":"Gold LS","year":"2009","journal-title":"Cutis"},{"key":"e_1_2_7_5_1","first-page":"37","article-title":"Fixed\u2010dose combination gel of adapalene and benzoyl peroxide plus doxycycline 100\u00a0mg versus oral isotretinoin for the treatment of severe acne: efficacy and cost analysis","volume":"7","author":"Penna P","year":"2014","journal-title":"Am Health Drug Benefits"},{"key":"e_1_2_7_6_1","first-page":"22","article-title":"In\u2010vivo effectiveness of adapalene 0.1%\/benzoyl peroxide 2.5% 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