{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:08:49Z","timestamp":1759741729472},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research from the Ministry of Health, Labor and Welfare in Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T\u2010lymphotropic virus type 1 (HTLV\u20101) induces adult T\u2010cell leukemia\/lymphoma (ATLL), HTLV\u20101\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) and carrier. ATLL is a mature CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>CCR4<jats:sup>+<\/jats:sup> T\u2010cell neoplasm, and approximately half of patients have direct skin involvement manifesting patch, plaque, tumor, multiple papules, erythroderma and purpura. However, there exist secondary eruptions without tumor cell infiltration in patients with ATLL or HAM\/TSP and carriers of HTLV\u20101. To clarify the presence of reactive skin eruptions in HTLV\u20101\u2010infected individuals, we reviewed our patients with HTLV\u20101\u2010associated diseases. In 2002\u20132012, we saw 50 ATLL or HAM\/TSP patients and HTLV\u20101 carriers presenting with skin lesions. We retrospectively selected cases that histologically showed lichenoid tissue reactions with predominant infiltration of CD8<jats:sup>+<\/jats:sup> T cells, but not CD4<jats:sup>+<\/jats:sup> tumor cells. The cases included erythroderma (HTLV\u20101 carrier), lichen planus (HTLV\u20101 carrier), alopecia areata (HAM\/TSP), chronic actinic dermatitis (HTLV\u20101 carrier to acute ATLL conversion) and discoid lupus erythematosus (smoldering ATLL). They were graft\u2010versus\u2010host disease\u2010like, major secondary lesions and seen in HTLV\u20101 carriers and patients with HAM\/TSP and smoldering ATLL. We coin the term HTLV\u20101\u2010associated lichenoid dermatitis (HALD) to encompass the conditions. HALD may occur in association with the elevated immunity toward HTLV\u20101\u2010infected CD4<jats:sup>+<\/jats:sup> T cells, thus sharing the pathogenetic role of cytotoxic T cells with HAM\/TSP.<\/jats:p>","DOI":"10.1111\/1346-8138.12980","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T05:15:15Z","timestamp":1434431715000},"page":"967-974","source":"Crossref","is-referenced-by-count":9,"title":["Human T\u2010lymphotropic virus 1 (HTLV\u20101)\u2010associated lichenoid dermatitis induced by CD8<sup>+<\/sup> T cells in HTLV\u20101 carrier, HTLV\u20101\u2010associated myelopathy\/tropical spastic paraparesis and adult T\u2010cell leukemia\/lymphoma"],"prefix":"10.1111","volume":"42","author":[{"given":"Yoshiki","family":"Tokura","sequence":"first","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisuke","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Occupational and Environmental Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Occupational and Environmental Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kasuya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu 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