{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T17:01:04Z","timestamp":1732035664784},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research on Intractable Diseases from the Ministry of Health, Labor and Welfare of Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Syndecan\u20101 is a member of the transmembrane heparan sulfate proteoglycan family, whose membrane\u2010bound and soluble forms are involved in wound healing, inflammation and vascular biology. Because these physiological events are implicated in the pathogenesis of systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c), we investigated the clinical association of serum syndecan\u20101 levels in this disease. Serum syndecan\u20101 levels were significantly higher in<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients, both in diffuse cutaneous<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c (dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) and limited cutaneous<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c (lc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c), than in healthy individuals, while comparable between dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and lc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c groups. In late stage dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients (disease duration of &gt;6\u00a0years), but not non\u2010late stage dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients (\u22646\u00a0years), serum syndecan\u20101 levels were significantly higher than in normal controls. More importantly,<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with elevated serum syndecan\u20101 levels had higher prevalence of telangiectasia, elevated right ventricular systolic pressure and decreased diffuse capacity of the lung for carbon monoxide than those with normal levels. Therefore, soluble syndecan\u20101 may be related to the development of proliferative vasculopathy in<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients.<\/jats:p>","DOI":"10.1111\/1346-8138.12986","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T07:15:34Z","timestamp":1434438934000},"page":"63-66","source":"Crossref","is-referenced-by-count":9,"title":["Serum level of circulating syndecan\u20101: A possible association with proliferative vasculopathy in systemic sclerosis"],"prefix":"10.1111","volume":"43","author":[{"given":"Ching\u2010Ying","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"},{"name":"Department of Dermatology Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Su","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00758.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel295"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297913100015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209168"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01624.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12365571"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1016-8478(23)07324-7","article-title":"Molecular and cellular mechanisms of syndecans in tissue injury and inflammation","volume":"24","author":"Bartlett AH","year":"2007","journal-title":"Mol Cells"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2010.545846"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e318280298f"},{"key":"e_1_2_7_11_1","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy EC","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-012-1307-4"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200011)43:11<2437::AID-ANR10>3.0.CO;2-U"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10775"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090593"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12986","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T14:40:09Z","timestamp":1717944009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,16]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/1346-8138.12986"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12986","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,16]]}}}