{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:21:58Z","timestamp":1773008518984,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Abstract<\/jats:title>We report a case involving a 62\u2010year\u2010old woman with in\u00a0vivo<\/jats:italic>\u2010bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS<\/jats:styled-content>) and basement membrane zone (BMZ<\/jats:styled-content>). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological findings suggested IgG\/IgA pemphigus. Direct immunofluorescence (IF<\/jats:styled-content>) showed in\u00a0vivo<\/jats:italic>\u2010bound IgG and IgA antibodies in the ICS<\/jats:styled-content> and BMZ<\/jats:styled-content>, whereas indirect IF<\/jats:styled-content> showed circulating IgG but not IgA antibodies in the ICS<\/jats:styled-content> and BMZ<\/jats:styled-content>. The anti\u2010ICS<\/jats:styled-content> IgG bound to desmoglein\u20103, while the anti\u2010BMZ<\/jats:styled-content> antibodies bound to the epidermal side of 1\u00a0mol\/L NaCl\u2010split skin. To the best of our knowledge, only two similar cases have been reported so far. Furthermore, we also examined IgG subclass distribution of the in\u00a0vivo<\/jats:italic>\u2010bound and circulating anti\u2010ICS<\/jats:styled-content> and BMZ<\/jats:styled-content> antibodies, and found that IgG1, IgG2 and IgG4 bound to ICS<\/jats:styled-content> of the lesional skins, while IgG1 and IgG3 bound to the BMZ<\/jats:styled-content>. The circulating anti\u2010ICS<\/jats:styled-content> antibodies belonged to IgG1 and IgG4, while the circulating anti\u2010BMZ<\/jats:styled-content> antibodies to IgG1, IgG2 and IgG4.<\/jats:p>We report a case involving a 62\u2010year\u2010old woman with in\u00a0vivo<\/jats:italic>\u2010bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS<\/jats:styled-content>) and basement membrane zone (BMZ<\/jats:styled-content>). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological findings suggested IgG\/IgA pemphigus. Direct immunofluorescence (IF<\/jats:styled-content>) showed in\u00a0vivo<\/jats:italic>\u2010bound IgG and IgA antibodies in the ICS<\/jats:styled-content> and BMZ<\/jats:styled-content>, whereas indirect IF<\/jats:styled-content> showed circulating IgG but not IgA antibodies in the ICS<\/jats:styled-content> and BMZ<\/jats:styled-content>. The anti\u2010ICS<\/jats:styled-content> IgG bound to desmoglein\u20103, while the anti\u2010BMZ<\/jats:styled-content> antibodies bound to the epidermal side of 1\u00a0mol\/L NaCl\u2010split skin. To the best of our knowledge, only two similar cases have been reported so far. Furthermore, we also examined IgG subclass distribution of the in\u00a0vivo<\/jats:italic>\u2010bound and circulating anti\u2010ICS<\/jats:styled-content> and BMZ<\/jats:styled-content> antibodies, and found that IgG1, IgG2 and IgG4 bound to ICS<\/jats:styled-content> of the lesional skins, while IgG1 and IgG3 bound to the BMZ<\/jats:styled-content>. The circulating anti\u2010ICS<\/jats:styled-content> antibodies belonged to IgG1 and IgG4, while the circulating anti\u2010BMZ<\/jats:styled-content> antibodies to IgG1, IgG2 and IgG4.<\/jats:p>","DOI":"10.1111\/1346-8138.13041","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T06:43:10Z","timestamp":1438152190000},"page":"194-196","source":"Crossref","is-referenced-by-count":3,"title":["Case of pemphigus with immunoglobulin G and A antibodies, binding to both the intercellular spaces and basement membrane zone"],"prefix":"10.1111","volume":"43","author":[{"given":"Satomi","family":"Hosoda","sequence":"first","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akimasa","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Komine","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamitaro","family":"Ohtsuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1974.01630060027007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051827"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01360.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12050"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.125499"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.10.061"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12143"},{"key":"e_1_2_6_9_1","first-page":"1081","article-title":"Unique autoimmune bullous dermatosis presenting with in\u00a0vivo IgG deposition in intercellular spaces and dermpepidermal junctions: report of five cases and analyzes of IgG subclasses","volume":"116","author":"Yokokura H","year":"2006","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00081.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-007-0734-0"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13041","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:14:16Z","timestamp":1695546856000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,29]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/1346-8138.13041"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13041","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,29]]}}}