{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:45:18Z","timestamp":1762004718833},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) is an autoimmune blistering disease caused by autoantibodies against type <jats:styled-content style=\"fixed-case\">XVII<\/jats:styled-content> collagen\/<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180). Although the mechanisms of autoantibody production remain to be elucidated, herpes virus infections have been identified as a possible triggering factor for pemphigus. We report a case of herpes zoster (<jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>) having anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 serum antibodies. The patient developed sudden\u2010onset, tense blisters and edematous erythema on the right anterior chest, shoulder and upper back. Histopathology showed remarkable degeneration of keratinocytes, acantholysis and blister formation with ballooning cells, indicating herpes virus infection. A polymerase chain reaction analysis of varicella zoster virus (<jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>) was positive in crusts and effusions from the skin lesions, confirming the definitive diagnosis of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>. Notably, we found that the patient had anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 serum antibodies in association with the occurrence of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>. After successful treatment with valacyclovir hydrochloride for 7\u00a0days, the serum levels of anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 antibodies decreased in accordance with the improvement of skin lesions. These findings suggest that the production of anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 antibodies could be triggered by the reactivation of <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.13042","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T06:49:10Z","timestamp":1437979750000},"page":"197-199","source":"Crossref","is-referenced-by-count":11,"title":["Possible enhancement of <scp>BP<\/scp>180 autoantibody production by herpes zoster"],"prefix":"10.1111","volume":"43","author":[{"given":"Koji","family":"Kamiya","sequence":"first","affiliation":[{"name":"Department of Dermatology Toyokawa City Hospital Toyokawa Japan"},{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kawasaki Hospital Kawasaki Medical School Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Niwa","sequence":"additional","affiliation":[{"name":"Department of General Medicine Toei Hospital Kitashitara\u2010gun Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Horio","sequence":"additional","affiliation":[{"name":"Department of Dermatology Toyokawa City Hospital Toyokawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Nishio","sequence":"additional","affiliation":[{"name":"Department of Dermatology Toyokawa City Hospital Toyokawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Tokura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.12.001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12479"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03201.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00107.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12082"},{"issue":"11","key":"e_1_2_5_7_1","first-page":"1328","article-title":"Bullous pemphigoid after herpes zoster vaccine administration: association or coincidence?","volume":"10","author":"Chacon GR","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10929.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.02.011"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12906"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12872"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.04.012"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.180"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20022031"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13042","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:14:18Z","timestamp":1695546858000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,27]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/1346-8138.13042"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13042","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,27]]}}}