{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T11:04:03Z","timestamp":1763809443722},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["no.\u00a081071301"],"award-info":[{"award-number":["no.\u00a081071301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["no.\u00a07132203"],"award-info":[{"award-number":["no.\u00a07132203"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) is an autoimmune subepidermal bullous disease, and different immunoglobulin (Ig)G autoantibody subclasses may play different roles in the pathogenesis of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. This study aims to evaluate the relationship between specific IgG subclasses and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. Enzyme\u2010linked immunoassays (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>) were developed to test the IgG subclasses targeting the non\u2010collagenous 16A (<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>16A) domain of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180. A statistical analysis was carried out to assess the relationship of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and IgG subclasses as well as other factors. The correlation coefficients between the <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> scores for four IgG subclasses and disease severity scores were 0.586 for IgG, 0.441 for IgG1, 0.594 for IgG2, 0.345 for IgG3, and 0.448 for IgG4 before treatment. After treatment, the correlation coefficient was 0.376 for IgG, 0.522 for IgG1, 0.314 for IgG2, 0.582 for IgG3 and 0.503 for IgG4. Spearman's rank correlation coefficient was 0.801 for IgG1, 0.66 for IgG2, 0.575 for IgG3 and 0.463 for IgG4 between the <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> scores of IgG subclasses and the disease severity score variation. The <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> scores of IgG subclasses in patients with mucosal involvement were higher than those without. Survival analysis showed that sex, IgG1 and IgG4 were the independent predictors for <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. In conclusion, the serum levels of IgG1 and IgG4 targeting <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>16A were paralleled with disease severity in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients. IgG1 and IgG4 and sex were the independent prognostic factors for an early prognosis of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.13051","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T08:35:08Z","timestamp":1440405308000},"page":"141-148","source":"Crossref","is-referenced-by-count":20,"title":["Serum levels of immunoglobulins G1 and G4 targeting the non\u2010collagenous 16A domain of <scp>BP<\/scp>180 reflect bullous pemphigoid activity and predict bad prognosis"],"prefix":"10.1111","volume":"43","author":[{"given":"Xi\u2010Ping","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Institute of Basic Medicine Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Institute of Basic Medicine Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Xia","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Gang","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue\u2010Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 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