{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:06:47Z","timestamp":1773270407591,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T00:00:00Z","timestamp":1439856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Verrucous skin lesions on the feet in diabetic neuropathy (<jats:styled-content style=\"fixed-case\">VSLDN<\/jats:styled-content>) develop in areas with sensory loss in diabetic patients. Although various types of chronic stimulation, such as pressure or friction, are considered an important factor in the development of such lesions, the precise pathogenesis of <jats:styled-content style=\"fixed-case\">VSLDN<\/jats:styled-content> remains obscure, and there is currently no established treatment for this disease. Here, we present a case of <jats:styled-content style=\"fixed-case\">VSLDN<\/jats:styled-content> on the dorsum of the right foot. However, because lymphedema was also observed at the same site, this lesion could also be diagnosed as elephantiasis nostras verrucosa arising in diabetic neuropathy. The lesion was successfully treated with a combination of elastic stocking and mixed killed bacterial suspension and hydrocortisone ointment, which suggested that <jats:styled-content style=\"fixed-case\">VSLDN<\/jats:styled-content> might have been exacerbated by the pre\u2010existing lymphedema. Because various types of chronic stimulation can trigger <jats:styled-content style=\"fixed-case\">VSLDN<\/jats:styled-content>, treatment plans should be devised on a case\u2010by\u2010case basis. Therefore, it is important to investigate the presence of factors that can induce or exacerbate chronic inflammatory stimulation, such as lymphedema in our case, in each patient with <jats:styled-content style=\"fixed-case\">VSLDN<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.13063","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T09:52:28Z","timestamp":1439891548000},"page":"329-331","source":"Crossref","is-referenced-by-count":4,"title":["Verrucous lesions arising in lymphedema and diabetic neuropathy: Elephantiasis nostras verrucosa or verrucous skin lesions on the feet of patients with diabetic neuropathy?"],"prefix":"10.1111","volume":"43","author":[{"given":"Eri","family":"Hotta","sequence":"first","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaro","family":"Okuzawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Hanada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Nomiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideya","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norito","family":"Katoh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb06946.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1997.tb02295.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2003.tb00388.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01479.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1684\/ejd.2012.1640","article-title":"Verrucous skin lesions on the feet in diabetic neuropathy successfully treated with topical maxacalcitol","volume":"22","author":"Murao K","year":"2012","journal-title":"Eur J Dermatol."},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12171"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12395564"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200809030-00001"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13063","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T11:46:56Z","timestamp":1713181616000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,18]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/1346-8138.13063"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13063","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,18]]}}}