{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:31:55Z","timestamp":1782786715790,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81130030"],"award-info":[{"award-number":["81130030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81000694"],"award-info":[{"award-number":["81000694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glucocorticoids are the first\u2010line treatment for pemphigus vulgaris. Among 140 patients receiving systemic glucocorticoids, 124 patients achieved complete remission off or on a prednisone dose of \u226410\u00a0mg\/day or less for 6\u00a0months or more. The mean average steroid controlling doses were 0.65, 0.62, 0.80, 1.08 and 1.38\u00a0mg\/kg per day for the mucosal\u2010dominant patients and the mild, moderate, severe and extensive cutaneous\u2010involved patients, respectively (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). The mean durations of the initial tapering after controlling doses started were 77.98, 48.78, 31.74 and 28.83\u00a0days when the disease was controlled with doses of 40\u00a0mg\/day or less, 45\u201360\u00a0mg\/day, 65\u201380\u00a0mg\/day and more than 80\u00a0mg\/day for the cutaneous\u2010involved types, respectively (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.005). Of the patients, 79.51% achieved complete remission within 3\u00a0years, 98.36% within 5\u00a0years and all within 6\u00a0years, which corresponded to a 50% yearly reduction of glucocorticoid dose. These successfully treated patients indicate that a severity\u2010tailored initial dose of glucocorticoids, an initial tapering duration based on the initial dose and a subsequent 50% yearly tapering regimen may cure pemphigus vulgaris within 3\u20136\u00a0years.<\/jats:p>","DOI":"10.1111\/1346-8138.13071","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T19:14:26Z","timestamp":1441221266000},"page":"325-328","source":"Crossref","is-referenced-by-count":9,"title":["Yearly reduction of glucocorticoid dose by 50% as tapering schedule achieves complete remission for 124 pemphigus vulgaris patients"],"prefix":"10.1111","volume":"43","author":[{"given":"Mingyue","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking University First Hospital Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis of Dermatoses Beijing 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