{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:29:42Z","timestamp":1792733382927,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T00:00:00Z","timestamp":1444003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) is an autoimmune subepidermal blistering disorder that has been reported to be associated with malignancies. Some authors described several cases of pemphigoid associated with malignancies (<jats:styled-content style=\"fixed-case\">PAM<\/jats:styled-content>); however, the evidence of this correlation still remains controversial. Several theories have been postulated to explain the relationship between malignant neoplasms and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>; the main theory suggests that antibodies directed against tumor\u2010specific antigens of malignant cells may cross\u2010react with antigens (like <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> antigens) in the basement membrane zone leading to the formation of blisters. We performed an extensive review of the English published work focusing on the epidemiology, the pathogenetic theories and the clinical and histological aspects of the disease. We identified 40 cases of <jats:styled-content style=\"fixed-case\">PAM<\/jats:styled-content>: of these, seven cases were associated with hematological malignancies and 33 with solid tumors. Physicians should be aware of the existence of PAM and we suggest an oncological screening in early\u2010onset pemphigoid, in patients with a former oncological history, in those with signs and symptoms that could be related to a neoplasm and in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> refractory to common immunosuppressive therapy.<\/jats:p>","DOI":"10.1111\/1346-8138.13079","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T12:26:58Z","timestamp":1444048018000},"page":"125-133","source":"Crossref","is-referenced-by-count":43,"title":["Malignancies in bullous pemphigoid: A controversial association"],"prefix":"10.1111","volume":"43","author":[{"given":"Riccardo","family":"Balestri","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Specialized, Clinical and Experimental Medicine University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Magnano","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Specialized, Clinical and Experimental Medicine University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelangelo","family":"La Placa","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Specialized, Clinical and Experimental Medicine University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Patrizi","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Specialized, Clinical and Experimental Medicine University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Angileri","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Specialized, Clinical and Experimental Medicine University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Tengattini","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Specialized, Clinical and Experimental Medicine University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Bardazzi","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Specialized, Clinical and Experimental Medicine University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,5]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"152","article-title":"A pemphigoid eruption associated with carcinoma of the bronchus","volume":"54","author":"Rook AJ","year":"1968","journal-title":"Trans St Johns Hosp Dermatol 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