{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:39:48Z","timestamp":1787013588664,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T00:00:00Z","timestamp":1442188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006483","name":"Abbvie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"Abstract<\/jats:title>\n \n Patients with psoriasis, in particular those with severe disease, have an increased risk of cardiovascular (\n CV<\/jats:styled-content>\n ) events compared with the general population. The aim of the present study is to determine whether correlation between asymmetric dimethylarginine (\n ADMA<\/jats:styled-content>\n ) and osteoprotegerin (\n OPG<\/jats:styled-content>\n ), two biomarkers associated with\n CV<\/jats:styled-content>\n disease, and disease severity may exist in patients with moderate\u2010to\u2010severe psoriasis. We also aimed to establish if baseline serum levels of these two biomarkers could correlate with the degree of change in the clinical parameters of disease severity following the use of anti\u2010tumor necrosis factor (\n TNF<\/jats:styled-content>\n )\u2010\u03b1 therapy in these patients. This was a prospective study on a series of consecutive non\u2010diabetic patients with moderate\u2010to\u2010severe psoriasis who completed 6\u00a0months of therapy with anti\u2010\n TNF<\/jats:styled-content>\n \u2010\u03b1\u2010adalimumab. Patients with kidney disease, hypertension or body mass index of 35\u00a0kg\/m\n 2<\/jats:sup>\n or more were excluded. Metabolic and clinical evaluation was performed immediately prior to the onset of treatment and at month 6. Twenty\u2010nine patients were assessed. Unlike\n OPG<\/jats:styled-content>\n , a significant positive correlation between\n ADMA<\/jats:styled-content>\n and resistin serum levels was found at the onset of adalimumab and also after 6\u00a0months of biologic therapy. We also observed a positive correlation between the percent of body surface area affected (\n BSA<\/jats:styled-content>\n ) and\n ADMA<\/jats:styled-content>\n levels obtained before the onset of adalimumab and a negative correlation between baseline\n ADMA<\/jats:styled-content>\n levels and a 6\u2010month\n BSA<\/jats:styled-content>\n change compared with baseline results. In patients with moderate\u2010to\u2010severe psoriasis,\n ADMA<\/jats:styled-content>\n levels correlate with clinical markers of disease severity.\n <\/jats:p>","DOI":"10.1111\/1346-8138.13094","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T04:04:21Z","timestamp":1442203461000},"page":"389-394","source":"Crossref","is-referenced-by-count":14,"title":["Asymmetric dimethylarginine but not osteoprotegerin correlates with disease severity in patients with moderate\u2010to\u2010severe psoriasis undergoing anti\u2010tumor necrosis factor\u2010\u03b1 therapy"],"prefix":"10.1111","volume":"43","author":[{"given":"Trinitario","family":"Pina","sequence":"first","affiliation":[{"name":"Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases Rheumatology Division Hospital Universitario Marqu\u00e9s de Valdecilla IDIVAL Santander 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