{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:14:58Z","timestamp":1788326098237,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T00:00:00Z","timestamp":1445990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antibiotics are widely applied in management of acne vulgaris, which raises the issue of antibiotic resistance. Due to improper application and supervision of antibiotics, antibiotic resistance has become a serious problem in China. So, the efficacy of antimicrobial therapy in acne is unclear without an objective monitor of antibiotic resistance of <jats:italic>Propionibacterium acnes<\/jats:italic>. This cross\u2010sectional, multicenter observational study is aimed at understanding the status of antibiotic resistance in <jats:italic>P. acnes<\/jats:italic>, investigating the measures of acne management in China and analyzing the genotypes of antibiotic\u2010resistant strains of <jats:italic>P. acnes<\/jats:italic>. Altogether, 312 strains of <jats:italic>P. acnes<\/jats:italic> were collected from patients in five medical centers across central China after reviewing the corresponding medical history in detail. The samples underwent antibiotic susceptibility assays by agar dilution method with a total of 11 classes of antibiotics being tested. The antibiotic\u2010resistant strains were screened and further analyzed by investigation of the genotypes regarding 23S <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content>, 16S <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content> and <jats:italic>erm(X)<\/jats:italic>. The predominant resistance occurred in macrolides and lincomycin with an overall resistance rate of 47.8%. The resistance to tetracyclines was scarce with only two cases identified. The emergence of minimum inhibitory concentration elevation for tetracyclines is associated with its application history (<jats:italic>P<\/jats:italic> &lt; 0.005). The genotypes of the reported macrolide\u2013lincosamide\u2013streptogramin B resistance strains were also spotted in Chinese subjects while other resistance determinants may also exist. The tetracyclines have been proved to be vastly susceptible while macrolides and lincomycin face a serious resistance status in China.<\/jats:p>","DOI":"10.1111\/1346-8138.13149","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T10:38:27Z","timestamp":1446028707000},"page":"406-413","source":"Crossref","is-referenced-by-count":27,"title":["Multicenter cross\u2010sectional observational study of antibiotic resistance and the genotypes of <i>Propionibacterium acnes<\/i> isolated from Chinese patients with acne vulgaris"],"prefix":"10.1111","volume":"43","author":[{"given":"Yukun","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Southwest Hospital Affiliated to The Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Southwest Hospital Affiliated to The Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Hospital of Wuhan Tongji Medical College Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology The Second People's Hospital of Chengdu Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology The First Hospital Affiliated to The Kunming Medical University Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Xijing Hospital Affiliated to The Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchieh","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_6_3_1","first-page":"201","article-title":"Prevalence and risk factors of Acne Vulgaris in adolescents 10 to 18 years of age","volume":"32","author":"Wu TQ","year":"2006","journal-title":"Int J Dermatol Venerol"},{"key":"e_1_2_6_4_1","first-page":"214","article-title":"Epidemiological study of the treatment in Acne Vulgaris patients","volume":"18","author":"Wu Y","year":"2004","journal-title":"Chin J Derm 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