{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:40:29Z","timestamp":1787316029140,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Jansen-Cilag"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Psoriasis is a chronic inflammatory skin disease whose clinical characteristics vary from patient to patient. We aimed to analyze how comorbidities and quality of life (QoL, as per the Dermatology Life Quality Index [\n                    <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>\n                    ]) may be affected by a family history of psoriasis and by age. The\n                    <jats:styled-content style=\"fixed-case\">ARIZONA<\/jats:styled-content>\n                    study was a multicenter, cross\u2010sectional study in 1022 adult patients diagnosed with moderate to severe psoriasis at least 6 months prior to inclusion. The severity of psoriasis and the proportion of patients with comorbidities were not affected by the presence of a family history. The regression analysis revealed that the presence of a family history of psoriasis was associated with the effect on the patient's QoL (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.002), regardless of disease severity. The mean\n                    <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>\n                    total score varied significantly across age groups (5.1 \u00b1 5.3 for the 18\u201330\u2010year group, 5.7 \u00b1 6.5 for the 31\u201360\u2010year group and 3.8 \u00b1 5.1 for the &gt;60\u2010year group;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.001). In conclusion, the presence of a family history of psoriasis appears to disrupt QoL in patients with moderate to severe psoriasis, but it hardly affected the prevalence of comorbid conditions. The effect of age on QoL was particularly noticeable in younger patients, highlighting its negative impact. As expected, older patients appeared to be burdened with a higher number of comorbidities than their younger counterparts.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.13157","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T11:47:31Z","timestamp":1444736851000},"page":"395-401","source":"Crossref","is-referenced-by-count":38,"title":["Effect of a family history of psoriasis and age on comorbidities and quality of life in patients with moderate to severe psoriasis: Results from the\n                    <scp>ARIZONA<\/scp>\n                    study"],"prefix":"10.1111","volume":"43","author":[{"given":"Jose Luis","family":"L\u00f3pez\u2010Estebaranz","sequence":"first","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"S\u00e1nchez\u2010Carazo","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sulleiro","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Janssen Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61128-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a015354"},{"key":"e_1_2_7_4_1","first-page":"504","article-title":"Prevalence of psoriasis in Spain in the age of biologics","volume":"105","author":"Ferrandiz C","year":"2014","journal-title":"Actas dermo\u2010sifiliograficas"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.339"},{"key":"e_1_2_7_6_1","first-page":"780","article-title":"Psychiatric and psychological comorbidities in patients with psoriasis\u2010 a 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