{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T16:34:42Z","timestamp":1746549282826},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T00:00:00Z","timestamp":1445990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 61\u2010year\u2010old Japanese man developed bullous skin lesions during topical therapy for psoriasis vulgaris. Physical examination demonstrated numerous tense bullae and scaly erythemas on the trunk and extremities. Histopathology of the skin biopsy demonstrated subepidermal bullae and lymphocytic infiltration with eosinophils in the dermis. Direct immunofluorescence revealed linear deposits of immunoglobulin (Ig)G, IgA and C3 along the basement membrane zone. Indirect immunofluorescence of 1 mol\/L NaCl\u2010split skin showed IgG reactivity with both epidermal and the dermal sides. IgM reactivity with both the epidermal and dermal sides was also detected. Enzyme\u2010linked immunosorbent assays showed negative results for both <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>230. Immunoelectrophoresis of serum and bone marrow aspiration revealed underlying primary macroglobulinemia with M\u2010proteinemia of IgM\u2010\u03ba type. Immunoblot analysis revealed IgG, but not IgM, antibodies to recombinant protein of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 C\u2010terminal domain. We diagnosed the present case as bullous pemphigoid with IgG anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 C\u2010terminal domain autoantibodies associated with primary macroglobulinemia and psoriasis vulgaris. Systemic administration of prednisolone 30 mg\/day resulted in dramatic improvement of both bullous and psoriatic skin lesions. When the bullous and psoriatic lesions relapsed, <jats:styled-content style=\"fixed-case\">DRC<\/jats:styled-content> chemotherapy (dexamethasone, rituximab and cyclophosphamide) for macroglobulinemia was performed. Then, the psoriatic lesions improved and the bullous lesions disappeared. We suggested that the present case may be paraneoplastic syndrome of bullous pemphigoid associated with primary macroglobulinemia and psoriasis vulgaris.<\/jats:p>","DOI":"10.1111\/1346-8138.13170","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T07:01:13Z","timestamp":1446015673000},"page":"571-574","source":"Crossref","is-referenced-by-count":14,"title":["Possible paraneoplastic syndrome case of bullous pemphigoid with immunoglobulin G anti\u2010<scp>BP<\/scp>180 C\u2010terminal domain antibodies associated with psoriasis and primary macroglobulinemia"],"prefix":"10.1111","volume":"43","author":[{"given":"Nobuki","family":"Maki","sequence":"first","affiliation":[{"name":"Department of Dermatology Jichi Medical University Saitama Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Demitsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Saitama Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoka","family":"Umemoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Saitama Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Saitama Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinobu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Saitama Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Kakurai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Saitama Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Saitama Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Saitama Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norito","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.02.036"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01599.x"},{"key":"e_1_2_5_4_1","first-page":"579A","article-title":"Bullous pemphigoid due to a 19S monoclonal paraprotein in a patient with Waldenstr\u04e7m's macroglobulinemia","volume":"26","author":"Wuepper KD","year":"1978","journal-title":"Clin Res"},{"key":"e_1_2_5_5_1","first-page":"199","article-title":"Bullous dermatosis associated with dysglobulinemia (two cases):relationships with epidermolysis bullosa acquisita","volume":"36","author":"Gompel A","year":"1982","journal-title":"Biomed Pharmacother"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb01162.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.9.1127"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1999.tb02070.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12166"},{"key":"e_1_2_5_10_1","first-page":"8","article-title":"Is there a linear IgM dermatosis? 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