{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:13:53Z","timestamp":1785392033940,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T00:00:00Z","timestamp":1449878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>While daylight photodynamic therapy (PDT) is a simpler and more tolerable treatment procedure for both clinicians and patients, it has never been applied for acne treatment. In this study, we evaluated efficacy, safety and histological changes of facial acne after application of the novel variant of 5\u2010aminolevulinate (ALA)\u2010ester, 1.5% 3\u2010butenyl ALA\u2010bu gel, using daylight only as the potential visible light source. Forty\u2010six acne patients were randomly assigned to either ALA\u2010bu or vehicle application group in a double\u2010blind fashion. Both groups applied the allocated gel to facial acne lesions every other day for 12 weeks. At the final 12 week, both inflammatory and non\u2010inflammatory acne lesions had decreased significantly by 58.0% and 34.1% in the ALA\u2010bu group, respectively. Only a few patients expressed mild adverse effects. In the histopathological analysis, attenuated inflammatory cell infiltrations were observed and immunostaining intensities for interleukin\u20108, interleukin\u20101\u03b2, matrix metalloproteinase\u20109 and phosphorylated nuclear factor\u2010\u03baB were reduced concomitantly. Changes of their mRNA expression demonstrated comparable patterns. In conclusion, this ambulatory PDT was effective, very well tolerated and convenient for treating inflammatory acne lesions. Experimental results correlated well with clinical results. This novel regimen would provide a viable option for acne therapy.<\/jats:p>","DOI":"10.1111\/1346-8138.13191","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T10:15:45Z","timestamp":1449915345000},"page":"515-521","source":"Crossref","is-referenced-by-count":30,"title":["Daylight photodynamic therapy with 1.5% 3\u2010butenyl 5\u2010aminolevulinate gel as a convenient, effective and safe therapy in acne treatment: A double\u2010blind randomized controlled trial"],"prefix":"10.1111","volume":"43","author":[{"given":"Hyuck Hoon","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul Korea"},{"name":"Acne Research Laboratory Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Rang","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chonnam National University Medical 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