{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:39:49Z","timestamp":1787013589823,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Abstract<\/jats:title>\n \n Psoriasis has been shown to accompany systemic inflammation. We aimed to examine serum C\u2010reactive protein (\n CRP<\/jats:styled-content>\n ) levels in Japanese psoriatic patients, and to elucidate their long\u2010term as well as short\u2010term changes by treatment with different biologics. A retrospective study was conducted in those who initiated and successfully continued the treatment for up to 24 months with either infliximab, adalimumab or ustekinumab, at the psoriasis special clinic of Jikei University School of Medicine. A total of 212 patients were included, 171 with plaque\u2010type psoriasis (PsV) and 41 with psoriatic arthritis (PsA). A statistically significant elevation of\n CRP<\/jats:styled-content>\n values was found in the group with a Psoriasis Area and Severity Index (\n PASI<\/jats:styled-content>\n ) of 12 or more compared with the\n PASI<\/jats:styled-content>\n of less than 12 for both PsV and PsA. The\n CRP<\/jats:styled-content>\n \u2010positive patients had a higher proportion of PsA compared with the\n CRP<\/jats:styled-content>\n \u2010negative patients, and they had significantly higher\n PASI<\/jats:styled-content>\n scores. Serum\n CRP<\/jats:styled-content>\n values declined as early as at 3 months after systemic treatment with biologics. Tumor necrosis factor (\n TNF<\/jats:styled-content>\n )\u2010\u03b1 antagonists did lead to a notable and sustained\n CRP<\/jats:styled-content>\n decline up to 24 months. Infliximab showed rapid decline, while\n CRP<\/jats:styled-content>\n decline by adalimumab treatment was time\u2010dependent. The interleukin\u201012\/23 p40 antagonist, ustekinumab, appeared to be less potent than\n TNF<\/jats:styled-content>\n \u2010\u03b1 antagonists in stabilizing\n CRP<\/jats:styled-content>\n values at low levels despite good control of cutaneous lesions. In conclusion, serum\n CRP<\/jats:styled-content>\n levels can be used to assess disease severity in Japanese psoriatic patients as a marker of systemic inflammation.\n TNF<\/jats:styled-content>\n \u2010\u03b1 antagonists may be more beneficial than ustekinumab in this regard.\n <\/jats:p>","DOI":"10.1111\/1346-8138.13213","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T10:25:58Z","timestamp":1450952758000},"page":"779-784","source":"Crossref","is-referenced-by-count":37,"title":["Serum C\u2010reactive protein levels in Japanese patients with psoriasis and psoriatic arthritis: Long\u2010term differential effects of biologics"],"prefix":"10.1111","volume":"43","author":[{"given":"Akihiko","family":"Asahina","sequence":"first","affiliation":[{"name":"Department of Dermatology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Umezawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Yanaba","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04410.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12768"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12257"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03527.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12118"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12372"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08628.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006450"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12355"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12632"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08334.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24172"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.04.003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10883.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-012-0002-8"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12239"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12331"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.454"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204741"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13645"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.5728"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.2502"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0007-0963.2004.05891.x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:40:05Z","timestamp":1695537605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,24]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/1346-8138.13213"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13213","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,24]]}}}