{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T23:45:36Z","timestamp":1785714336572,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurofibromatosis type 1 (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1) has many reported clinical characteristics. We previously found that <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 patients (especially men) had lower body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) than controls, but the reason has not been elucidated. To address this issue, a retrospectively case\u2013control study was conducted. Anthropometric and serum chemistry data that potentially relate to <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> were collected from medical records of <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 patients and their age\u2010 and sex\u2010matched controls. Enrollment of 98 adult patients who underwent skin surgery with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 (41 men, 57 women) and 173 without <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 (74 men, 99 women) were investigated. The median <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in male <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 patients was significantly lower than that of the controls. Triglycerides in male <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 patients were significantly lower than male controls, creatine kinase and lactate dehydrogenase in <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 patients were also lower than controls, aspartate aminotransferase and alanine aminotransferase showed a lower tendency in <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 patients, but were significantly lower in female patients. With correlation analysis, lactate dehydrogenase was moderately correlated with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in male <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 patients. Creatine kinase and creatinine showed no statistical correlation with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in either group. Triglycerides and alanine aminotransferase showed a positive correlation with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in both male and female controls, but not in <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 patients. In conclusion, only lactate dehydrogenase was moderately correlated with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> in male <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 patients, although results of some nutritional and metabolic parameters suggest a specific metabolism in <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1.<\/jats:p>","DOI":"10.1111\/1346-8138.13218","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T15:25:48Z","timestamp":1450970748000},"page":"799-803","source":"Crossref","is-referenced-by-count":20,"title":["Nutritional, muscular and metabolic characteristics in patients with neurofibromatosis type 1"],"prefix":"10.1111","volume":"43","author":[{"given":"Monji","family":"Koga","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Fukuoka University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Medicine of Sensory and Motor Organs Division of Dermatology Faculty of Medicine Tottori University Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Imafuku","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Fukuoka University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1004(200006)15:6<541::AID-HUMU6>3.0.CO;2-N"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2009.04.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2113"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1663"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307380201700806"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.075937"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12611"},{"key":"e_1_2_6_9_1","first-page":"161","article-title":"Skeletal muscle and motor deficits in Neurofibromatosis Type 1","volume":"15","author":"Summers MA","year":"2015","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_6_10_1","first-page":"15","article-title":"Muscular force is reduced in neurofibromatosis type 1","volume":"9","author":"Souza JF","year":"2009","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2014.12.021"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520290115023"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19991203)87:4<317::AID-AJMG7>3.0.CO;2-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000250332.89420.e6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.31.11.853"},{"key":"e_1_2_6_16_1","unstructured":"Ministry of Health Labour and Welfare Japan.The National Health and Nutrition Survey in Japan 2012 (in Japanese). Available from: URL:http:\/\/www.mhlw.go.jp\/bunya\/kenkou\/eiyou\/h24-houkoku.html(Accessed Feb 22 2015)."},{"key":"e_1_2_6_17_1","first-page":"1204","volume-title":"Textbook of Nephrology","author":"Massry SG","year":"2001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt515"},{"key":"e_1_2_6_19_1","first-page":"15","article-title":"Association between elevated serum alanine aminotransferase and cardiometabolic risk factors in rural Chinese population: a cross\u2010sectional study","volume":"10","author":"Chen S","year":"2015","journal-title":"BMC Cardiovasc Disord"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13218","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:40:14Z","timestamp":1695552014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,24]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/1346-8138.13218"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13218","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,24]]}}}