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Epigenetics, such as <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> methylation, histone modification, long non\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>, could explain the crossroad between genetics and environmental factors. For instance, epigenetics is associated with environmental factors, which may cause the breakdown of immune tolerance and the development of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c in patients with a particular genetic background. In the future, further investigations of the interplay between genetics and epigenetics will be beneficial to elucidate the complex molecular cross\u2010talk and heterogeneity in the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c pathogenesis. 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