{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:23:44Z","timestamp":1791894224137,"version":"4.3.4"},"reference-count":114,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T00:00:00Z","timestamp":1457136000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Scientific Research (B)","award":["15H04887"],"award-info":[{"award-number":["15H04887"]}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","award":["15H06280"],"award-info":[{"award-number":["15H06280"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inherited ichthyoses are a group of genetic disorders characterized by generalized dry skin, scaling and hyperkeratosis, and often associated with erythroderma. These manifestations are due to mutations in genes mostly involved in skin barrier formation. Inherited ichthyoses consist of non\u2010syndromic ichthyoses and ichthyosis syndromes. Non\u2010syndromic ichthyoses are characterized by the phenotypic expression of the disorder being seen only in the skin. Non\u2010syndromic ichthyoses include ichthyosis vulgaris, recessive X\u2010linked ichthyosis, autosomal recessive congenital ichthyosis, keratinopathic ichthyosis and other forms. This review focuses on updates for each type of non\u2010syndromic ichthyosis, highlighting molecular mechanisms and phenotype\/genotype correlations. Included in autosomal recessive congenital ichthyosis are three of the major phenotypes (harlequin ichthyosis, lamellar ichthyosis and congenital ichthyosiform erythroderma) and three of the minor subtypes (self\u2010healing collodion baby, acral self\u2010healing collodion baby and bathing suit ichthyosis). Keratinopathic ichthyosis is proposed as an umbrella term for ichthyoses caused by mutations in keratin genes. Next\u2010generation sequencing technologies have become powerful tools for the diagnosis of inherited ichthyoses and the discovery of their genetic causes. This article reviews the current understanding of molecular pathomechanisms for non\u2010syndromic ichthyoses and explores future perspectives.<\/jats:p>","DOI":"10.1111\/1346-8138.13243","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T04:34:13Z","timestamp":1457238853000},"page":"242-251","source":"Crossref","is-referenced-by-count":164,"title":["Inherited ichthyosis: Non\u2010syndromic forms"],"prefix":"10.1111","volume":"43","author":[{"given":"Takuya","family":"Takeichi","sequence":"first","affiliation":[{"name":"Department of Dermatology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagoya University Graduate School of Medicine Nagoya 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