{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:30:39Z","timestamp":1791397839904,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To clarify the relationship between major cutaneous microorganisms (<jats:italic>Propionibacterium<\/jats:italic>,<jats:italic> Staphylococcus<\/jats:italic> and <jats:italic>Malassezia<\/jats:italic> spp.) and acne vulgaris (acne), we examined the microbiota quantitatively in the follicular contents of inflammatory acne and on the facial skin of patients with acne. Fifteen Japanese untreated acne outpatients were studied. The follicular contents from inflammatory acne lesions of the face were collected using a comedo extractor. The skin surface samples were obtained by the swab method from 10 cm<jats:sup>2<\/jats:sup> of facial skin. The microbiota was analyzed using polymerase chain reaction. The microbiota in follicular contents was similar to that on the skin surface, namely, there were large populations of <jats:italic>Propionibacterium<\/jats:italic> spp., <jats:italic>Staphylococcus<\/jats:italic> spp. and <jats:italic>Malassezia<\/jats:italic> spp. Moreover, the number of <jats:italic>Malassezia<\/jats:italic> spp. on the skin surface was correlated with that of inflammatory acne and that in follicular contents. This study clarified that there are large populations of <jats:italic>Propionibacterium<\/jats:italic> spp., <jats:italic>Staphylococcus<\/jats:italic> spp. and <jats:italic>Malassezia<\/jats:italic> spp. in follicular contents. These results suggest the possibility that not only <jats:italic>Propionibacterium acnes<\/jats:italic> but also other cutaneous resident microorganisms are related to acne. Particularly, we considered that <jats:italic>Malassezia<\/jats:italic> spp. is closely related.<\/jats:p>","DOI":"10.1111\/1346-8138.13245","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T15:25:58Z","timestamp":1450970758000},"page":"906-911","source":"Crossref","is-referenced-by-count":49,"title":["Microorganisms inhabiting follicular contents of facial acne are not only <i>Propionibacterium<\/i> but also <i>Malassezia<\/i> spp."],"prefix":"10.1111","volume":"43","author":[{"given":"Narifumi","family":"Akaza","sequence":"first","affiliation":[{"name":"Research Laboratories Nippon Menard Cosmetic Nagoya Japan"},{"name":"Department of Dermatology Fujita Health University School of Medicine Toyoake Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Akamatsu","sequence":"additional","affiliation":[{"name":"Department of Applied Cell and Regenerative Medicine Fujita Health University School of Medicine 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