{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:28:09Z","timestamp":1740144489623,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,1,30]],"date-time":"2016-01-30T00:00:00Z","timestamp":1454112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Abstract<\/jats:title>Interleukin (IL<\/jats:styled-content>)\u201021 is regarded as a potent antitumor agent, which increases the cytotoxicity of both natural killer (NK<\/jats:styled-content>) and CD<\/jats:styled-content>8+<\/jats:sup> T cells. In this study, we investigated the role of IL<\/jats:styled-content>\u201021 in mycosis fungoides (MF<\/jats:styled-content>). IL<\/jats:styled-content>\u201021 mRNA<\/jats:styled-content> expression levels in patch and plaque MF<\/jats:styled-content> were significantly higher than those in normal skin. IL<\/jats:styled-content>\u201021 mRNA<\/jats:styled-content> expression levels in tumor MF<\/jats:styled-content> were significantly decreased compared with those in patch and plaque MF<\/jats:styled-content>. Interestingly, mRNA<\/jats:styled-content> expression levels of IL<\/jats:styled-content>\u201021 in MF<\/jats:styled-content> lesional skin significantly correlated with those of T\u2010helper type\u20101 cytokines\/chemokines such as CXCL<\/jats:styled-content>10, CXCL<\/jats:styled-content>11 and \u03b3\u2010interferon. Immunohistochemistry showed that IL<\/jats:styled-content>\u201021 was expressed by keratinocytes in patch and plaque MF<\/jats:styled-content>. Furthermore, serum IL<\/jats:styled-content>\u201021 levels in patients with tumor MF<\/jats:styled-content> were significantly lower than those of healthy controls and plaque MF<\/jats:styled-content>. Thus, IL<\/jats:styled-content>\u201021 expression was significantly downregulated in skin and blood of patients with tumor MF<\/jats:styled-content>, which may contribute to progression of MF<\/jats:styled-content>. Our study suggests that recombinant IL<\/jats:styled-content>\u201021 would be a promising therapy for MF.<\/jats:p>","DOI":"10.1111\/1346-8138.13278","type":"journal-article","created":{"date-parts":[[2016,1,30]],"date-time":"2016-01-30T07:14:47Z","timestamp":1454138087000},"page":"819-822","source":"Crossref","is-referenced-by-count":4,"title":["Decreased interleukin\u201021 expression in skin and blood in advanced mycosis fungoides"],"prefix":"10.1111","volume":"43","author":[{"given":"Miyoko","family":"Kabasawa","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Tokyo Tokyo Japan"},{"name":"Department of Regenerative Medicine Research Institute National Center for Global Health and Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Sugaya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Tokyo Tokyo 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