{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:47:23Z","timestamp":1791474443991,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:00:00Z","timestamp":1455494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"County Council of V\u00e4sterbotten"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary hyperhidrosis affects approximately 3% of the population and reduces quality of life in affected persons. Few studies have investigated the symptoms of anxiety, depression and hazardous alcohol consumption among those with hyperhidrosis and the effect of treatment with botulinum toxin. The first aim of this study was to investigate the effect of primary hyperhidrosis on mental and physical health, and alcohol consumption. Our second aim was to study whether and how treatment with botulinum toxin changed these effects. One hundred and fourteen patients answered questionnaires regarding hyperhidrosis and symptoms, including hyperhidrosis disease severity scale (<jats:styled-content style=\"fixed-case\">HDSS<\/jats:styled-content>), visual analog scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) 10\u2010point scale for hyperhidrosis symptoms, hospital anxiety and depression scale (<jats:styled-content style=\"fixed-case\">HADS<\/jats:styled-content>), alcohol use disorder identification test (<jats:styled-content style=\"fixed-case\">AUDIT<\/jats:styled-content>) and short\u2010form health survey (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036) before treatment with botulinum toxin and 2 weeks after. The age of onset of hyperhidrosis was on average 13.4 years and 48% described heredity for hyperhidrosis. Significant improvements were noted in patients with axillary and palmar hyperhidrosis regarding mean <jats:styled-content style=\"fixed-case\">HDSS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> VAS<\/jats:styled-content> 10\u2010point scale, <jats:styled-content style=\"fixed-case\">HADS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SF<\/jats:styled-content>\u201036 and sweat\u2010related health problems 2 weeks after treatment with botulinum toxin. Changes in mean <jats:styled-content style=\"fixed-case\">AUDIT<\/jats:styled-content> for all participants were not significant. Primary hyperhidrosis mainly impairs mental rather than physical aspects of life and also interferes with specific daily activities of the affected individuals. Despite this, our patients did not show signs of anxiety, depression or hazardous alcohol consumption. Treatment with botulinum toxin reduced sweat\u2010related problems and led to significant improvements in <jats:styled-content style=\"fixed-case\">HDSS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> VAS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HADS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 in our patients.<\/jats:p>","DOI":"10.1111\/1346-8138.13291","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T07:53:18Z","timestamp":1455522798000},"page":"928-933","source":"Crossref","is-referenced-by-count":27,"title":["Primary hyperhidrosis: Implications on symptoms, daily life, health and alcohol consumption when treated with botulinum toxin"],"prefix":"10.1111","volume":"43","author":[{"given":"Alexander","family":"Shayesteh","sequence":"first","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Dermatology and Venereology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Boman","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Dermatology and Venereology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urban","family":"Janlert","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Epidemiology and Global Health Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Brulin","sequence":"additional","affiliation":[{"name":"Department of Nursing Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Nylander","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Dermatology and Venereology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32334.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.5.772"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(97)00014-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.119507"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/02844317609105198"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.029"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-009-0006-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33192.x"},{"key":"e_1_2_7_11_1","first-page":"152","article-title":"Presynaptic actions of botulinal neurotoxins at vertebrate neuromuscular junctions","volume":"84","author":"Molgo J","year":"1990","journal-title":"J Physiol (Paris)"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(03)90041-5"},{"key":"e_1_2_7_13_1","first-page":"2433","article-title":"Botulinum toxin helps against primary local hyperhidrosis. 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