{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T22:32:35Z","timestamp":1764714755143},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:00:00Z","timestamp":1455494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) is believed to be caused by a complex interplay between genetic factors and environmental influences. Although silicone has been considered to be a candidate of environmental agents, clinical data presented so far fail to show a significant association between silicone breast implant (<jats:styled-content style=\"fixed-case\">SBI<\/jats:styled-content>) and the development of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. Because we recently experienced two consecutive <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with anti\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> polymerase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">RNAP III<\/jats:styled-content>) antibody who underwent <jats:styled-content style=\"fixed-case\">SBI<\/jats:styled-content>, we here investigated the association of <jats:styled-content style=\"fixed-case\">SBI<\/jats:styled-content> history with the development of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c positive for anti\u2010<jats:styled-content style=\"fixed-case\">RNAP III<\/jats:styled-content> antibody. Among 262 Japanese <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients, of note, the frequency of <jats:styled-content style=\"fixed-case\">SBI<\/jats:styled-content> history was significantly higher in the anti\u2010<jats:styled-content style=\"fixed-case\">RNAP III<\/jats:styled-content> antibody group (16.0% [4\/25]) than in the anti\u2010topoisomerase I antibody group (0% [0\/87], <jats:italic>P<\/jats:italic> &lt; 0.005) and in the anticentromere antibody group (1.2% [2\/150], <jats:italic>P<\/jats:italic> &lt; 0.005). These results suggest that <jats:styled-content style=\"fixed-case\">SBI<\/jats:styled-content> could influence the development of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c in a certain subset of patients with anti\u2010<jats:styled-content style=\"fixed-case\">RNAP III<\/jats:styled-content> antibody.<\/jats:p>","DOI":"10.1111\/1346-8138.13292","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T11:01:51Z","timestamp":1455534111000},"page":"808-810","source":"Crossref","is-referenced-by-count":11,"title":["Association of anti\u2010<scp>RNA<\/scp> polymerase <scp>III<\/scp> antibody and silicone breast implants in patients with systemic sclerosis"],"prefix":"10.1111","volume":"43","author":[{"given":"Ryosuke","family":"Saigusa","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Ichimura","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zenshiro","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00758.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0505-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.128"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.06.004"},{"key":"e_1_2_6_6_1","first-page":"159","article-title":"Scleroderma and silicone breast implants","volume":"167","author":"Whorton D","year":"1997","journal-title":"West J 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