{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:38:08Z","timestamp":1784806688948,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Novartis Pharmaceuticals"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Generalized pustular psoriasis (<jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content>) is a severe inflammatory skin disease characterized by the presence of sterile pustules covering almost the entire body and systemic symptoms such as fever. Secukinumab, a fully human\u2010recombinant anti\u2010interleukin\u201017A monoclonal antibody was indicated for psoriasis vulgaris and psoriatic arthritis in Japan but is not yet investigated for <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content>. In this phase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, open\u2010label multicenter single arm study, the efficacy and safety of secukinumab as monotherapy or with co\u2010medication was evaluated in 12 Japanese patients with <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content>. All the patients received secukinumab 150 mg s.c. at baseline, week 1, 2, 3 and 4, and then every 4 weeks. Two non\u2010responders were up\u2010titrated to 300 mg. Change in <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content> severity from baseline was evaluated by clinical global impression (<jats:styled-content style=\"fixed-case\">CGI<\/jats:styled-content>) categorized as \u201cworsened\u201d, \u201cno change\u201d, \u201cminimally improved\u201d, \u201cmuch improved\u201d or \u201cvery much improved\u201d. Treatment success was achieved by 83.3% (<jats:italic>n<\/jats:italic> = 10) of patients at week 16 (primary end\u2010point) with <jats:styled-content style=\"fixed-case\">CGI<\/jats:styled-content> evaluated as \u201cvery much improved\u201d (<jats:italic>n<\/jats:italic> = 9) and \u201cmuch improved\u201d (<jats:italic>n<\/jats:italic> = 1). Moreover, the area of erythema with pustules improved as early as week 1 and resolved by week 16 in most of the patients. The improvements were sustained throughout 52 weeks. Over the 52\u2010week treatment period, secukinumab was well tolerated with no unexpected safety signals. Nasopharyngitis, urticaria, diabetes mellitus and arthralgia were the frequent adverse events reported. The data from this study shows that secukinumab can become one of the potent treatment options for <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.13306","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T12:44:14Z","timestamp":1456490654000},"page":"1011-1017","source":"Crossref","is-referenced-by-count":167,"title":["Efficacy and safety of secukinumab in patients with generalized pustular psoriasis: A 52\u2010week analysis from phase <scp>III<\/scp> open\u2010label multicenter Japanese study"],"prefix":"10.1111","volume":"43","author":[{"given":"Shinichi","family":"Imafuku","sequence":"first","affiliation":[{"name":"Department of Dermatology Fukuoka University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Honma","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukari","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Komine","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamitaro","family":"Ohtsuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akimichi","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagoya City University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Seko","sequence":"additional","affiliation":[{"name":"Department of Biometrics and Statistical Sciences Novartis Pharma K.K. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Clinical Trial Management Group Novartis Pharma K.K. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Clinical Resource and Development Novartis Pharma K.K. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Immunology and Dermatology Clinical Franchise Novartis Pharma K.K. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13614"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.230"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01145.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"e_1_2_7_6_1","unstructured":"Japanese Dermatological Association 2015.Japanese Dermatological Guidelines for General Pustular Psoriasis. 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