{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:58:58Z","timestamp":1779375538122,"version":"3.53.1"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T00:00:00Z","timestamp":1457222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008695","name":"Japan Foundation for Applied Enzymology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Abstract<\/jats:title>The interaction of programmed death\u20101 (PD<\/jats:styled-content>\u20101) with its ligand, programmed death ligand\u20101 (PD<\/jats:styled-content>\u2010L1), has been considered to play a key role in the negative regulation of immune responses. Patients with diffuse cutaneous systemic sclerosis (SS<\/jats:styled-content>c) had higher levels of soluble PD<\/jats:styled-content>\u20101 (sPD<\/jats:styled-content>\u20101) than those with limited cutaneous SS<\/jats:styled-content>c and healthy individuals. Serum sPD<\/jats:styled-content>\u20101 levels positively correlated with the severity of skin sclerosis. In contrast, serum sPD<\/jats:styled-content>\u2010L1 levels were significantly increased in patients with SS<\/jats:styled-content>c compared with healthy individuals. Moreover, serum sPD<\/jats:styled-content>\u2010L1 levels were not associated with the extent of skin sclerosis and were elevated not only in patients with diffuse cutaneous SS<\/jats:styled-content>c, but also in those with limited cutaneous SS<\/jats:styled-content>c. These results suggested that serum sPD<\/jats:styled-content>\u20101 levels may increase in patients with SS<\/jats:styled-content>c and correlate with the severity of skin sclerosis. PD<\/jats:styled-content>\u20101\/PD<\/jats:styled-content>\u2010L1 interaction may contribute to the development of skin sclerosis in SSc.<\/jats:p>","DOI":"10.1111\/1346-8138.13339","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T11:28:43Z","timestamp":1457263723000},"page":"954-957","source":"Crossref","is-referenced-by-count":40,"title":["Serum levels of soluble programmed death\u20101 and programmed death ligand\u20101 in systemic sclerosis: Association with extent of skin sclerosis"],"prefix":"10.1111","volume":"43","author":[{"given":"Koichi","family":"Yanaba","sequence":"first","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuha","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2014.05.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.05.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20022119"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20022125"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27500"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310207"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370313"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2013.823517"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/8.5.765"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.10.6738"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20883"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2014.12.008"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13339","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:23:06Z","timestamp":1695511386000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,6]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/1346-8138.13339"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13339","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,6]]}}}