{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:09:39Z","timestamp":1785863379432,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Atopic dermatitis (AD) is a chronic relapsing eczematous skin disease. Certain populations of patients are resistant to standard therapies with topical steroids and\/or calcineurin inhibitors, and require systemic medication, such as immunosuppressants. Recently, several reports have shed light on the anti\u2010allergic effects of carotenoids. Therefore, we investigated the effect of p.o. administration of \u03b2\u2010carotene or lycopene on AD\u2010like symptoms of <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u20101 hairless mice fed with a low zinc\/magnesium diet. Mice were divided into four groups: (i) fed with a standard diet (Co group); (ii) low zinc\/magnesium diet (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> group); (iii) low zinc\/magnesium and \u03b2\u2010carotene diet (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010C group); and (iv) low zinc\/magnesium and lycopene diet (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010L group). They were then fed these diets for 8 weeks. Severities of dermatitis were assessed by their appearance, and histopathological and hematological observations. Mice in the <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> group developed AD\u2010like dermatitis both clinically and histologically. <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010C and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010L group mice also developed xerosis and wrinkle\u2010like skin changes, but they were milder than those of <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> group mice. Histological analysis revealed that epidermis thickening and inflammatory cell infiltration in the skin of the <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010C and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010L groups were both statistically less than those of the <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> group. The concentration of thymus and activation regulated chemokine in the skin of the <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010L group and the concentration of <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>27 in the skin of the <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010C group were significantly lower than those of the <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> group, respectively. In conclusion, p.o. administration of \u03b2\u2010carotene or lycopene prevents AD\u2010like symptoms in association with a suppression of T\u2010helper 2 chemokines in a murine model. Ingestion of carotenoids may be beneficial for patients with AD.<\/jats:p>","DOI":"10.1111\/1346-8138.13350","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T10:41:04Z","timestamp":1458384064000},"page":"1188-1192","source":"Crossref","is-referenced-by-count":20,"title":["Oral administration of \u03b2\u2010carotene or lycopene prevents atopic dermatitis\u2010like dermatitis in <scp>HR<\/scp>\u20101 mice"],"prefix":"10.1111","volume":"43","author":[{"given":"Makiko","family":"Hiragun","sequence":"first","affiliation":[{"name":"Department of Dermatology Integrated Health Sciences Institute of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Hiragun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Integrated Health Sciences Institute of Biomedical and Health Sciences Hiroshima University Hiroshima 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