{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T06:12:49Z","timestamp":1695622369008},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of immunoglobulin G4\u2010related disease (IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>) which presented with prurigo on the trunk and extremities. A 66\u2010year\u2010old man had a 2\u2010month history of itchy erythematous papules on his trunk and extremities. Bilateral eyelid swelling and enlargement of the submandibular and parotid glands were also observed. Computed tomography revealed pleural thickening and diffuse pancreatic enlargement. Serum levels of IgG4 were markedly increased. A biopsy specimen obtained from an erythematous papule showed a perivascular inflammatory infiltrate of lymphocytes with eosinophils in the dermis, whereas a parotid gland biopsy revealed an infiltrate of abundant IgG4\u2010positive plasma cells. Treatment with prednisolone resulted in improvement of the skin and other lesions along with a decrease in IgG4 serum levels. A flow cytometric assay revealed that percentages of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20104\u2010 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013\u2010producing <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells were markedly higher in the circulation of the IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> patient than in that of healthy subjects. Moreover, those populations dramatically decreased after treatment. Thus, prurigo may be a skin manifestation of IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> and T\u2010helper 2 cells may contribute to the pathogenesis.<\/jats:p>","DOI":"10.1111\/1346-8138.13372","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:11:39Z","timestamp":1459383099000},"page":"1067-1070","source":"Crossref","is-referenced-by-count":0,"title":["Immunoglobulin G4\u2010related disease presenting with prurigo: Circulating T\u2010helper 2 cells may be involved in the pathogenesis"],"prefix":"10.1111","volume":"43","author":[{"given":"Saori","family":"Takamura","sequence":"first","affiliation":[{"name":"Department of Dermatology Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Suyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Teraki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saitama Medical Center Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60720-0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13296"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12325"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.029"},{"key":"e_1_2_5_6_1","first-page":"17","article-title":"Two cases of IgG4\u2010related disease accompanied by pruritic eruptions with an infiltration of plasmacytes and eosinophilis into the dermis","volume":"123","author":"Ikezawa Y","year":"2013","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.183"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12641"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12342"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2760"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12154"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13372","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:52:31Z","timestamp":1695552751000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,30]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/1346-8138.13372"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13372","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,30]]}}}