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Oral ulcers, genital ulcers, cutaneous lesions, and ocular and articular involvement are the most frequent features of the disease. Mucocutaneous lesions are considered hallmarks of the disease, and often precede other manifestations. Therefore, their recognition may permit earlier diagnosis and treatment with beneficial results for prognosis.\n                    <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\n                    is particularly prevalent in \u201cSilk Route\u201d populations but has a global distribution. The disease usually starts around the third or fourth decade of life. Sex distribution is roughly equal. The diagnosis is based on clinical criteria, as there is no pathognomonic test. Genetic factors have been investigated extensively, and association with human leukocyte antigen (\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    )\u2010B51 is still known as the strongest genetic susceptibility factor. The T\u2010helper 17 and interleukin (\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    )\u201017 pathways are active, and play an important role, particularly in acute attacks of\n                    <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\n                    . Neutrophil activity is increased in\n                    <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\n                    , and the affected organs show a significant neutrophil and lymphocyte infiltration.\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    \u2010B51 association and increased\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017 response are thought to play a role in neutrophil activation. Treatment is mainly based on the suppression of inflammatory attacks of the disease using immunomodulatory and immunosuppressive agents. Although treatment has become much more effective in recent years with the introduction of newer drugs,\n                    <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\n                    is still associated with considerable morbidity and increased mortality. Male sex, younger age of onset and increased number of organs involved at the diagnosis are associated with a more severe disease and, therefore, require more aggressive treatment.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.13381","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T02:42:54Z","timestamp":1460601774000},"page":"620-632","source":"Crossref","is-referenced-by-count":238,"title":["Beh\u00e7et's disease: A comprehensive review with a focus on epidemiology, etiology and clinical features, and management of mucocutaneous lesions"],"prefix":"10.1111","volume":"43","author":[{"given":"Erkan","family":"Alpsoy","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Akdeniz University School of Medicine Antalya 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