{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:47:42Z","timestamp":1784918862436,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Presenile diffuse familial sebaceous hyperplasia (<jats:styled-content style=\"fixed-case\">PDFSH<\/jats:styled-content>) presents as extensive yellowish papules with central umbilication on the face without involvement of periorificial regions and occurs in adolescents or young adults with a positive family history. Thirteen cases of <jats:styled-content style=\"fixed-case\">PDFSH<\/jats:styled-content> have been reported in the English\u2010language published work, 10 of which responded to oral isotretinoin from 0.5 to 1 mg\/kg per day but recurrences were often observed. Herein, we report two cases of <jats:styled-content style=\"fixed-case\">PDFSH<\/jats:styled-content>, which were successfully managed without recurrence with prolonged low\u2010dose isotretinoin (0.2 mg\/kg per day, a cumulative dose of 41 and 64 mg\/kg, respectively). Treatment protocols among different published works were reviewed to verify the efficacy of isotretinoin.<\/jats:p>","DOI":"10.1111\/1346-8138.13416","type":"journal-article","created":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T11:29:14Z","timestamp":1462102154000},"page":"1205-1208","source":"Crossref","is-referenced-by-count":10,"title":["Presenile diffuse familial sebaceous hyperplasia successfully treated with low\u2010dose isotretinoin: A report of two cases and review of the published work"],"prefix":"10.1111","volume":"43","author":[{"given":"You\u2010Chen Serena","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology Hsinchu Cathay General Hospital Hsinchu City Taiwan"},{"name":"Department of Dermatology Cathay General Hospital Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Pin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cathay General Hospital Taipei City Taiwan"},{"name":"Department of Dermatology National Taiwan University Hospital Taipei City Taiwan"},{"name":"Department of Dermatology National Taiwan University Hospital Hsinchu Branch Hsinchu City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan\u2010I","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cathay General Hospital Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chang\u2010Gung Memorial Hospital Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cathay General Hospital Taipei City Taiwan"},{"name":"Department of Dermatology National Taiwan University Hospital Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1980.tb01689.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70345-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70082-3"},{"key":"e_1_2_6_5_1","first-page":"621","article-title":"Familial nevoid sebaceous gland hyperplasia affecting three generations of a family","volume":"9","author":"Weisshaar E","year":"1999","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.162346"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)80128-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)80308-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1983.tb01796.x"},{"key":"e_1_2_6_10_1","first-page":"31","article-title":"Diffuse (presenile) hyperplasia of the sebaceous glands, a new entity? 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