{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:03:13Z","timestamp":1789941793912,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:00:00Z","timestamp":1466985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Mycobacterium lepromatosis<\/jats:italic>, an independent species from <jats:italic>Mycobacterium leprae<\/jats:italic>, has been found to be a causative agent for diffuse lepromatous leprosy (<jats:styled-content style=\"fixed-case\">DLL<\/jats:styled-content>) in Mexico, but remains poorly studied. Here, the drug resistance\u2010determining regions (<jats:styled-content style=\"fixed-case\">DRDR<\/jats:styled-content>) of <jats:italic>folP1, rpoB<\/jats:italic> and <jats:italic>gyrA<\/jats:italic> (conferring resistance to dapsone, rifampicin and quinolone, respectively) in <jats:italic>M. lepromatosis<\/jats:italic> from leprosy patients in Mexico were characterized. No mutations or silent mutations were found at previously characterized major sites in <jats:styled-content style=\"fixed-case\">DRDR<\/jats:styled-content> of <jats:italic>M. lepromatosis<\/jats:italic>. However, a non\u2010synonymous mutation was found in codon 54 between two major sites of the <jats:italic>folP1 <\/jats:italic><jats:styled-content style=\"fixed-case\">DRDR<\/jats:styled-content> in <jats:italic>M. lepromatosis<\/jats:italic> sequences. All <jats:italic>M. lepromatosis<\/jats:italic> isolates showed <jats:styled-content style=\"fixed-case\">CAG<\/jats:styled-content> sequence in codon 54 of <jats:italic>folP1<\/jats:italic>. Because the next codons 53 and 55 are known as major mutation sites for drug resistance, more detailed analysis using more samples is needed to determine whether it influences susceptibility to dapsone and\/or efficiency of folate biosynthesis in <jats:italic>M. lepromatosis<\/jats:italic> or not.<\/jats:p>","DOI":"10.1111\/1346-8138.13483","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T06:46:08Z","timestamp":1467009968000},"page":"1345-1349","source":"Crossref","is-referenced-by-count":11,"title":["Mutations in the drug resistance\u2010determining region of <i>Mycobacterium lepromatosis<\/i> isolated from leprosy patients in Mexico"],"prefix":"10.1111","volume":"43","author":[{"given":"Masanori","family":"Kai","sequence":"first","affiliation":[{"name":"Department of Mycobacteriology Leprosy Research Center National Institute of Infectious Diseases Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Fafutis\u2010Morris","sequence":"additional","affiliation":[{"name":"University of Guadalajara\/Instituto Dermatologico de Jalisco Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Mycobacteriology Leprosy Research Center National Institute of Infectious Diseases Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Mycobacteriology Leprosy Research Center National Institute of Infectious Diseases Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mayorga\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"University of Guadalajara\/Instituto Dermatologico de Jalisco Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio","family":"Rodriguez\u2010Castellanos","sequence":"additional","affiliation":[{"name":"University of Guadalajara\/Instituto Dermatologico de Jalisco Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Alonso","family":"Mart\u00ednez\u2010Guzman","sequence":"additional","affiliation":[{"name":"University of Guadalajara\/Instituto Dermatologico de Jalisco Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Mycobacteriology Leprosy Research Center National Institute of Infectious Diseases Tokyo 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