{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T22:51:46Z","timestamp":1768258306428,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:00:00Z","timestamp":1466985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["23591658"],"award-info":[{"award-number":["23591658"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["26461704"],"award-info":[{"award-number":["26461704"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We measured both serum anti\u2010phosphatidylserine\u2013prothrombin complex (anti\u2010<jats:styled-content style=\"fixed-case\">PSPT<\/jats:styled-content>) antibodies and anti\u2010moesin antibodies, as well as various cytokines (interleukin [<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>]\u20102, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, granulocyte macrophage colony\u2010stimulating factor, \u03b3\u2010interferon, tumor necrosis factor\u2010\u03b1) levels in polyarteritis nodosa (<jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>) patients with cutaneous manifestations. All patients showed the presence of a histological necrotizing vasculitis in the skin specimen. They were treated with i.v. cyclophosphamide pulse therapy (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CY<\/jats:styled-content>) and prednisolone therapy or steroid pulse therapy. The immunological assessments were performed on sera collected prior to and after treatment with <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CY<\/jats:styled-content> or steroid pulse therapy. We found a significant positive correlation between serum anti\u2010moesin antibodies and both clinical Birmingham Vasculitis Activity Scores and Vasculitis Damage Index. Anti\u2010<jats:styled-content style=\"fixed-case\">PSPT<\/jats:styled-content> antibody and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102 levels after treatment in <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content> patients were significantly lower than before treatment. In contrast, anti\u2010moesin antibody levels were higher following <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CY<\/jats:styled-content> or steroid pulse therapy compared with the pretreatment levels. In the treatment\u2010resistant <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content> patients (<jats:italic>n<\/jats:italic> = 8), anti\u2010<jats:styled-content style=\"fixed-case\">PSPT<\/jats:styled-content> antibody levels after treatment were significantly lower than before treatment. In contrast, anti\u2010moesin antibody levels after treatment in the patients were significantly higher compared with the pretreatment levels. Immunohistochemical staining revealed moesin overexpression in mainly fibrinoid necrosis of the affected arteries in the <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content> patients. We suggest that measurement of serum anti\u2010<jats:styled-content style=\"fixed-case\">PSPT<\/jats:styled-content> antibody levels could serve as a marker for <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content> and aid in earlier diagnosis of <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>. We also propose that elevated serum anti\u2010moesin antibodies could play some role of the exacerbation in patients with <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.13491","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T06:50:56Z","timestamp":1467010256000},"page":"18-22","source":"Crossref","is-referenced-by-count":14,"title":["Presence of anti\u2010phosphatidylserine\u2013prothrombin complex antibodies and anti\u2010moesin antibodies in patients with polyarteritis nodosa"],"prefix":"10.1111","volume":"44","author":[{"given":"Tatsuro","family":"Okano","sequence":"first","affiliation":[{"name":"Department of Dermatology St Marianna University School of Medicine Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sora","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Marianna University School of Medicine Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinao","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Marianna University School of Medicine Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koya","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Science and Laboratory of Biosciences Graduate School of Frontier Biosciences Osaka University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Tsukita","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Science and Laboratory of Biosciences Graduate School of Frontier Biosciences Osaka University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Ishizu","sequence":"additional","affiliation":[{"name":"Department of Pathology\/Pathophysiology Division of Pathophysiological Science Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Health Protection Graduate School of Medicine Teikyo University Asia International Institute of Infectious Disease Control Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamihiro","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Marianna University School of Medicine Kawasaki 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