{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:58:03Z","timestamp":1777517883639,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research","award":["no. 24390274"],"award-info":[{"award-number":["no. 24390274"]}]},{"name":"Challenging Exploratory Research","award":["no. 20443955"],"award-info":[{"award-number":["no. 20443955"]}]},{"name":"the Ministry of Health, Labor and Welfare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oral lichen planus (OLP) is a chronic inflammatory disorder of the oral mucosa of unknown etiology. Clinically, the erosive type of OLP (erosive OLP) can show features similar to those of pemphigus vulgaris (PV), an autoimmune blistering disorder in which desmoglein (Dsg)3 is targeted. In addition to clinical and histopathological findings, immunological studies, including direct immunofluorescence (IF), indirect IF and enzyme\u2010linked immunosorbent assay (ELISA) that detect autoantibodies to Dsg3, are helpful in differentiating erosive OLP from PV. Here, we show two cases of erosive OLP with autoantibodies to Dsg3. Patient 1 was a 68\u2010year\u2010old woman with chronic erosions of the oral mucosa, in which elevated levels of immunoglobulin (Ig)G autoantibodies to Dsg1 and Dsg3 were detected by ELISA. Patient 2 was an 85\u2010year\u2010old woman with white striae with erosions on the lateral sides of the buccal mucosa with elevated levels of IgG autoantibodies to Dsg3 detected by ELISA. Histopathological findings from both cases showed lichenoid dermatitis, and both direct and indirect IF showed no tissue\u2010bound IgG autoantibodies. From these findings, the diagnosis of erosive OLP was made. Immunological assays revealed both cases to have IgG\u2010directing calcium\u2010independent linear epitopes on Dsg3, which are suggestive of non\u2010pathogenic autoantibodies. In addition, autoantibodies to Dsg3 in patient 2 reacted with a prosequence\u2010possessing precursor form of Dsg3 but not with the mature form of the molecule. The present study suggests that erosive OLP may develop anti\u2010Dsg3 autoantibodies, which should be carefully assessed.<\/jats:p>","DOI":"10.1111\/1346-8138.13493","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T07:22:47Z","timestamp":1469517767000},"page":"1350-1353","source":"Crossref","is-referenced-by-count":18,"title":["Two cases of erosive oral lichen planus with autoantibodies to desmoglein 3"],"prefix":"10.1111","volume":"43","author":[{"given":"Ken","family":"Muramatsu","sequence":"first","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Nishie","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Natsuga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamaki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Division of Oral Pathobiological Science Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Oral Pathobiological Science Hokkaido University Graduate School of Dental Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Asaka","sequence":"additional","affiliation":[{"name":"Department of Oral Pathobiological Science Hokkaido University Graduate School of Dental Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120452"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.61"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.41"},{"key":"e_1_2_6_5_1","first-page":"173","article-title":"A case of oral lichen planus in a patient with anti\u2010desmoglein antibodies (in Japanese)","volume":"8","author":"Kato T","year":"2009","journal-title":"Hifu"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12661"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10929.x"},{"key":"e_1_2_6_8_1","first-page":"53","article-title":"Serum autoantibodies to desmogleins 1 and 3 in patients with oral lichen planus","volume":"47","author":"Lukac J","year":"2006","journal-title":"Croat Med 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