{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:30:07Z","timestamp":1784752207483,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although studies regarding prevalence of metabolic syndrome (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) in Asian psoriatic patients are limited and show varying results, a previous report describes a significant increase in prevalence of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> in Thai psoriatic patients, as compared with rates in the general population. However, no significant association between <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> and psoriasis severity using the Psoriasis Area and Severity Index (<jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>) was found, which differs from the findings of Korean and Japanese studies. This study aimed at re\u2010evaluating the association between <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> and psoriasis severity in Thai patients using current assessment (<jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>) and chronological assessment (historical course and interventions). A total of 273 psoriatic patients were recruited. After controlling for age and sex, 96 patients were assigned to the <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> group and 96 patients to the non\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> group. Similar to the previous study, no significant differences were identified between metabolic and non\u2010metabolic patients regarding <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>, age of onset, disease duration and family history of psoriasis. However, the numbers of hospitalizations (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.018) and interventions (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.028) were significantly higher in metabolic patients than in non\u2010metabolic patients. Further, a greater number of metabolic components was significantly associated with a higher number of hospitalizations (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.012), pustular or erythrodermic psoriasis episodes (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.049), and interventions (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.005). Body mass index of 23\u00a0kg\/m<jats:sup>2<\/jats:sup> or more, abdominal obesity and high blood pressure were associated with an increased risk of treatment failure. Using chronological assessment, our study supported that <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> negatively affects psoriasis severity and treatment outcomes. Screening for <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> is highly recommended for psoriatic patients.<\/jats:p>","DOI":"10.1111\/1346-8138.13540","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T11:43:00Z","timestamp":1470915780000},"page":"1424-1428","source":"Crossref","is-referenced-by-count":20,"title":["Metabolic syndrome and psoriasis severity in South\u2010East Asian patients: An investigation of potential association using current and chronological assessments"],"prefix":"10.1111","volume":"43","author":[{"given":"Leena","family":"Chularojanamontri","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanisada","family":"Wongpraparut","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narumol","family":"Silpa\u2010Archa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pichanee","family":"Chaweekulrat","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060513502891"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.100474"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.72462"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.3.300"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.11.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.09.046"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.1.11"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12614"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.47102\/annals-acadmedsg.V38N1p66","article-title":"Rationale for redefining obesity in Asians","volume":"38","author":"Low S","year":"2009","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803346"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010539511424482"},{"key":"e_1_2_6_13_1","unstructured":"Dermatological Society of Thailand.Clinical Practice Guideline for psoriasis. 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