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Recent progress in the immunohistochemical diagnosis of sweat gland neoplasms is also reviewed. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>117 can help to distinguish sweat gland or sebaceous tumors from other non\u2010Merkel cell epithelial tumors of the skin. For immunohistochemical differential diagnosis between sweat gland carcinoma (<jats:styled-content style=\"fixed-case\">SGC<\/jats:styled-content>) other than primary cutanesous apocrine carcinoma and skin metastasis of breast carcinoma (<jats:styled-content style=\"fixed-case\">SMBC<\/jats:styled-content>), a panel of antibodies may be useful, including p63 (<jats:styled-content style=\"fixed-case\">SGC<\/jats:styled-content><jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">SMBC<\/jats:styled-content><jats:sup>\u2212<\/jats:sup>), <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>5\/6 (<jats:styled-content style=\"fixed-case\">SGC<\/jats:styled-content><jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">SMBC<\/jats:styled-content><jats:sup>\u2212<\/jats:sup>), podoplanin (<jats:styled-content style=\"fixed-case\">SGC<\/jats:styled-content><jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">SMBC<\/jats:styled-content><jats:sup>\u2212<\/jats:sup>) and mammaglobin (<jats:styled-content style=\"fixed-case\">SGC<\/jats:styled-content><jats:sup>\u2212<\/jats:sup>, <jats:styled-content style=\"fixed-case\">SMBC<\/jats:styled-content><jats:sup>+<\/jats:sup>). Comparison of antibodies used for immunohistochemical diagnosis of sebaceous carcinoma (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) suggests that adipophilin has the highest sensitivity and specificity. Some authors have found that immunostaining for survivin, androgen receptor and <jats:styled-content style=\"fixed-case\">ZEB<\/jats:styled-content>2\/<jats:styled-content style=\"fixed-case\">SIP<\/jats:styled-content>1 has prognostic value for ocular <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>, but not extraocular <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>. <jats:italic>In situ <\/jats:italic><jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> is rare, especially extraocular <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>, but there have been several recent reports that actinic keratosis and Bowen's disease are the source of invasive <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>. Finally, based on recent reports, classification of sebaceous neoplasms into three categories is proposed, which are sebaceoma (a benign neoplasm with well\u2010defined architecture and no atypia), borderline sebaceous neoplasm (low\u2010grade <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>; an intermediate tumor with well\u2010defined architecture and nuclear atypia) and <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> (a malignant tumor with invasive growth and evident nuclear atypia).<\/jats:p>","DOI":"10.1111\/1346-8138.13555","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T10:21:39Z","timestamp":1488536499000},"page":"315-326","source":"Crossref","is-referenced-by-count":19,"title":["Topics in histopathology of sweat gland and sebaceous neoplasms"],"prefix":"10.1111","volume":"44","author":[{"given":"Shin\u2010ichi","family":"Ansai","sequence":"first","affiliation":[{"name":"Division of Dermatology and 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