{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:17:20Z","timestamp":1771543040436,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T00:00:00Z","timestamp":1472428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> is the primary collagen in the basement membranes around blood vessels and in the dermoepidermal junction in the skin. Perivascular collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> is synthesized by endothelial cells and pericytes, and contributes to the homeostasis and remodeling of blood vessels. It has been well recognized that elevated serum collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> levels are associated with the liver fibrosis. The objective was to examine serum collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> levels and their clinical associations in patients with systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c), and to examine the expression of collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> in the fibrotic skin in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. Serum collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> levels in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients and diffuse cutaneous type <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients were significantly higher than those in healthy individuals. Serum collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> levels were positively correlated with modified Rodnan total skin score. Serum collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> levels in early stage (disease duration \u22643 years) diffuse cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients were significantly elevated. Serum collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> levels in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with digital ulcers (<jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>) were significantly elevated. In immunohistochemical staining, the expression of collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> around dermal small vessels in the affected skin was reduced compared with those of normal individuals. These results suggest that elevated serum collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> levels may be associated with the skin sclerosis in the early stage of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. The measurement of serum collagen type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> levels in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients may be useful as a disease activity marker in skin sclerosis and <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.13564","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T05:26:40Z","timestamp":1472448400000},"page":"167-172","source":"Crossref","is-referenced-by-count":20,"title":["Possible association of elevated serum collagen type <scp>IV<\/scp> level with skin sclerosis in systemic sclerosis"],"prefix":"10.1111","volume":"44","author":[{"given":"Sei\u2010ichiro","family":"Motegi","sequence":"first","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi 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