{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:44:58Z","timestamp":1783593898588,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>T\u2010cell immunoglobulin and mucin domain 3 (<jats:styled-content style=\"fixed-case\">TIM<\/jats:styled-content>\u20103) has been thought to play a crucial role in the negative regulation of immune responses. Here, we examined the levels of serum soluble <jats:styled-content style=\"fixed-case\">TIM<\/jats:styled-content>\u20103 (<jats:styled-content style=\"fixed-case\">sTIM<\/jats:styled-content>\u20103) in patients with systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) and evaluated the results with respect to the clinical features of the disease. Patients with diffuse cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c (dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) had higher levels of <jats:styled-content style=\"fixed-case\">sTIM<\/jats:styled-content>\u20103 than those with limited cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and healthy individuals. Serum <jats:styled-content style=\"fixed-case\">sTIM<\/jats:styled-content>\u20103 levels were positively correlated with the severity of skin sclerosis in early phase dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. Moreover, serum <jats:styled-content style=\"fixed-case\">sTIM<\/jats:styled-content>\u20103 levels were increased more often in patients with renal crisis and cardiac involvement than in those with normal <jats:styled-content style=\"fixed-case\">sTIM<\/jats:styled-content>\u20103 levels. These results suggest that serum <jats:styled-content style=\"fixed-case\">sTIM<\/jats:styled-content>\u20103 levels may be increased in patients with early phase dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and associated with cardiac involvement and renal crisis. Measurement of serum <jats:styled-content style=\"fixed-case\">sTIM<\/jats:styled-content>\u20103 may be useful for risk stratification in the early stage of the disease.<\/jats:p>","DOI":"10.1111\/1346-8138.13610","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T07:17:36Z","timestamp":1474442256000},"page":"194-197","source":"Crossref","is-referenced-by-count":17,"title":["Clinical significance of serum soluble <scp>T<\/scp>\u2010cell immunoglobulin and mucin domain 3 levels in systemic sclerosis: Association with disease severity"],"prefix":"10.1111","volume":"44","author":[{"given":"Miki","family":"Chiba","sequence":"first","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Yanaba","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuha","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13026"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.05.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939274"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/415536a"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni987"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4281"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1271"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.01.006"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310207"},{"key":"e_1_2_5_12_1","first-page":"3809","article-title":"Upregulation of Tim\u20103 on CD4+ T cells is associated with Th1\/Th2 imbalance in patients with allergic asthma","volume":"8","author":"Tang F","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1686-5"},{"key":"e_1_2_5_14_1","first-page":"275","article-title":"Longitudinal analysis of serum cytokine concentrations in systemic sclerosis: association of interleukin 12 elevation with spontaneous regression of skin sclerosis","volume":"33","author":"Matsushita T","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00858"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-008-9252-x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13610","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:08:34Z","timestamp":1695568114000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,21]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/1346-8138.13610"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13610","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,21]]}}}