{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:21:16Z","timestamp":1778498476053,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["24591620"],"award-info":[{"award-number":["24591620"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary cutaneous mucinous carcinoma (<jats:styled-content style=\"fixed-case\">PCMC<\/jats:styled-content>) is a rare sweat gland tumor characterized by the presence of abundant mucin around the tumor islands, but the molecular mechanisms for this structure are not well elucidated. Because mucin is epithelial in nature, it is likely to be produced by epithelial tumor cells, not by surrounding stromal cells. We hypothesized that the abundant mucin is a result of reversed cellular polarity of the tumor. To test this hypothesis, we conducted an immunohistological study to investigate expression of tight junction (<jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content>) proteins occludin and <jats:styled-content style=\"fixed-case\">ZO<\/jats:styled-content>\u20101 in <jats:styled-content style=\"fixed-case\">PCMC<\/jats:styled-content>, as well as in normal sweat glands and other sweat gland tumors. Dot\u2010like or linear expression of <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content> proteins was observed at ductal structures of sweat glands, and ductal or cystic structures of related tumors. In <jats:styled-content style=\"fixed-case\">PCMC<\/jats:styled-content>, however, <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content> protein expression was clearly visible at the edges of tumor cell islands. This study provides evidence to show that the characteristic histological structure of <jats:styled-content style=\"fixed-case\">PCMC<\/jats:styled-content> is caused by inverse polarization of the tumor cells, and that <jats:styled-content style=\"fixed-case\">TJ<\/jats:styled-content> proteins are useful markers of ductal differentiation in sweat gland tumors.<\/jats:p>","DOI":"10.1111\/1346-8138.13611","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T07:18:02Z","timestamp":1474442282000},"page":"444-448","source":"Crossref","is-referenced-by-count":2,"title":["Reversed cellular polarity in primary cutaneous mucinous carcinoma: A study on tight junction protein expression in sweat gland tumors"],"prefix":"10.1111","volume":"44","author":[{"given":"Yusuke","family":"Nagasawa","sequence":"first","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akemi","family":"Ishida\u2010Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000159104.02985.6b"},{"key":"e_1_2_7_3_1","volume-title":"Neoplasms with Apocrine Differentiation","author":"Requena L","year":"1998"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200305000-00002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1058-z"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01170.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031641"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-009-9150-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2008.11.005"},{"key":"e_1_2_7_10_1","volume-title":"Pathology of the Skin with Clinical Correlations","author":"McKee PH","year":"2005"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13611","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/chorus\/v1\/articles\/10.1111%2F1346-8138.13611","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:36:48Z","timestamp":1695472608000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,21]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/1346-8138.13611"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13611","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,21]]}}}