{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T04:13:30Z","timestamp":1695528810204},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,15]],"date-time":"2016-10-15T00:00:00Z","timestamp":1476489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As a novel administration method of ivermectin (<jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content>) for scabies treatment, we proposed a \u201cwhole\u2010body bathing method (<jats:styled-content style=\"fixed-case\">WBBM<\/jats:styled-content>)\u201d. In this method, the patients would bathe themselves in a bathing fluid containing <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content> at an effective concentration. Previously, we demonstrated that <jats:styled-content style=\"fixed-case\">WBBM<\/jats:styled-content> could deliver <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content> to the skin but not to the plasma in rats. In the present study, to assess the clinical validity of the method an arm bathing examination (first trial) and a whole\u2010body bathing examination (second trial) were conducted in healthy volunteers. In both the first and second trials, after bathing in fluid containing <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content>, the exposure in the stratum corneum was higher compared with that after taking <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content> p.o. as reported previously. <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content> was not detected in plasma at any sampling point after the whole\u2010body bathing in the second trial. Furthermore no serious adverse events were found. These results in both trials suggest that <jats:styled-content style=\"fixed-case\">WBBM<\/jats:styled-content> can deliver <jats:styled-content style=\"fixed-case\">IVM<\/jats:styled-content> to the human stratum corneum without systemic exposure or serious adverse effects in healthy volunteers, and at concentrations that would be adequate for scabies treatment.<\/jats:p>","DOI":"10.1111\/1346-8138.13628","type":"journal-article","created":{"date-parts":[[2016,10,15]],"date-time":"2016-10-15T07:56:52Z","timestamp":1476518212000},"page":"406-413","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacokinetics of ivermectin applied topically by whole\u2010body bathing method in healthy volunteers"],"prefix":"10.1111","volume":"44","author":[{"given":"Atsushi","family":"Miyajima","sequence":"first","affiliation":[{"name":"Department of Biopharmaceutics Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Tashiro","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yayoi","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmaceutical Preformulation Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehisa","family":"Hanawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmaceutical Preformulation Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kigure","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taichi","family":"Anata","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nae","family":"Yuasa","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machi","family":"Koshino","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Yuzawa","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Akagi","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yoshimasu","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniko","family":"Makigami","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"},{"name":"Tsubasa Home Care Clinic Funabashi Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayo","family":"Komoda","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Interventions for treating scabies","volume":"2","author":"Strong M","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00691.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1752-1"},{"key":"e_1_2_7_5_1","first-page":"19052","article-title":"A persistent problem with scabies in and outside a nursing home in Amsterdam: indications for resistance to lindane and ivermectin","volume":"13","author":"Hoek JA","year":"2008","journal-title":"Euro Surveill"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2011.05.014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32835e1d57"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct0910329"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12728"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13321"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2015.07.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2015.02.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00794.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.12.1618"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13628","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13628","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/chorus\/v1\/articles\/10.1111%2F1346-8138.13628","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:36:45Z","timestamp":1695472605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,15]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/1346-8138.13628"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13628","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,15]]}}}