{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:12:57Z","timestamp":1787155977960,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T00:00:00Z","timestamp":1480896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Approximately one in three persons will develop herpes zoster during their lifetime, and it can lead to serious complications such as postherpetic neuralgia. However, evidence on burden of herpes zoster and postherpetic neuralgia in Japan is limited. This prospective, observational, multicenter, physician practice\u2010based cohort study was conducted in Kushiro, Hokkaido, Japan (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/Clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link> identifier <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01873365) to assess the incidence and hospitalization rates of herpes zoster, and the proportion, clinical burden and risk factors for postherpetic neuralgia in adults aged 60 years or more. Within the study area, 800 subjects developed herpes zoster and 412 were eligible for the study. Herpes zoster incidence was 10.2\/1000 person\u2010years and higher among women and older subjects. Subjects with herpes zoster required on average 5.7 outpatient consultations. Herpes zoster\u2010associated hospitalization rate was 3.4% (27\/800). The proportion of postherpetic neuralgia and other complications was 9.2% (38\/412) and 26.5% (109\/412), respectively. Statistically significant association with the development of postherpetic neuralgia was male sex (odds ratio [OR], 2.51; 95% confidence interval [CI], 1.17\u20135.38), age of 70\u201374 years (OR, 3.51; 95% CI, 1.09\u201311.3), immunosuppressive therapy (OR, 6.44; 95% CI, 1.26\u201332.9), severe herpes zoster pain at first consultation (OR, 3.08; 95% CI, 1.10\u20138.62) and rash on upper arms (vs no rash on upper arms; OR, 3.46; 95% CI, 1.10\u201310.9). Considerable herpes zoster and postherpetic neuralgia burden exists among elderly in Japan, and there may be predictive factors at the first visit which could be indicative of the risk of developing postherpetic neuralgia.<\/jats:p>","DOI":"10.1111\/1346-8138.13639","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T07:05:01Z","timestamp":1480921501000},"page":"414-422","source":"Crossref","is-referenced-by-count":55,"title":["Burden of herpes zoster and postherpetic neuralgia in Japanese adults 60 years of age or older: Results from an observational, prospective, physician practice\u2010based cohort study"],"prefix":"10.1111","volume":"44","author":[{"given":"Keiko","family":"Sato","sequence":"first","affiliation":[{"name":"Healthoutcomes Department GSK K.K. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Adachi","sequence":"additional","affiliation":[{"name":"Kushiro Dermatology Clinic Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Kushiro City General Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Asano","sequence":"additional","affiliation":[{"name":"Asano Skin Clinic Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Sakuragaoka Dermatology Clinic Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riri","family":"Adachi","sequence":"additional","affiliation":[{"name":"Adachi Dermatology Cosmetic Surgery Clinic Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Kiuchi","sequence":"additional","affiliation":[{"name":"Kushiro Daiichi Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiju","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Kushiro Red Cross Hospital Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taizo","family":"Matsuki","sequence":"additional","affiliation":[{"name":"Healthoutcomes Department GSK K.K. 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