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According to the source of the substances, granulomatous diseases can be divided into two groups: infectious and non\u2010infectious. The mechanisms of infectious granuloma formation have been widely investigated because of its easy reproducibility in experimental models, both <jats:italic>in\u00a0vivo<\/jats:italic> and <jats:italic>in\u00a0vitro<\/jats:italic>. On the contrary, mechanisms of non\u2010infectious granuloma formation have not been well investigated because of the difficulty to reproduce this formation in experimental models. In this article, we review our recent understanding of the histogenesis and pathogenesis of granuloma formation, confirmed from studies of infectious granulomas, and we present potential hypotheses of the histogenesis and pathogenesis of non\u2010infectious granulomas based on clinical investigations.<\/jats:p>","DOI":"10.1111\/1346-8138.13662","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T10:21:39Z","timestamp":1488536499000},"page":"297-303","source":"Crossref","is-referenced-by-count":48,"title":["What is new in the histogenesis of granulomatous skin diseases?"],"prefix":"10.1111","volume":"44","author":[{"given":"Jun","family":"Asai","sequence":"first","affiliation":[{"name":"Department of Dermatology Kyoto prefectural University of Medicine Graduate School of Medical Science Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129744"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080908"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15952-7"},{"key":"e_1_2_10_5_1","first-page":"255","article-title":"Classification of leprosy according to immunity. 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