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The primary aim of this study is to investigate acitretin, methotrexate, cyclosporin efficacy, safety and drug survival rates in pediatric patients as well as predictors of drug survival. This is a multicenter study including 289 pediatric cases being treated with acitretin, methotrexate and cyclosporin in four academic referral centers. Efficacy, adverse events, reasons for discontinuation, 1, 2\u2010 and 3\u2010year drug survival rates, and determinants of drug survival were analyzed. A 75% reduction of Psoriasis Area and Severity Index score or better response rate was obtained in 47.5%, 34.1% and 40% of the patients who were treated with acitretin, methotrexate and cyclosporin, respectively. One\u2010year drug survival rates for acitretin, methotrexate and cyclosporin were 36.3%, 21.1% and 15.1%, respectively. The most significant determinant of drug survival, which diminished over time, was treatment response whereas arthritis, body mass index and sex had no influence. Although all three medications are effective and relatively safe in children, drug survival rates are low due to safety concerns at this age group. Effective disease control through their rational use can be expected to improve survival rates.<\/jats:p>","DOI":"10.1111\/1346-8138.13713","type":"journal-article","created":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T12:18:28Z","timestamp":1481372308000},"page":"630-634","source":"Crossref","is-referenced-by-count":36,"title":["Efficacy, safety and drug survival of conventional agents in pediatric psoriasis: A multicenter, cohort study"],"prefix":"10.1111","volume":"44","author":[{"given":"Tulin","family":"Ergun","sequence":"first","affiliation":[{"name":"Department of Dermatology Marmara University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Seckin Gencosmanoglu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Marmara University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan","family":"Alpsoy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Akdeniz University School of Medicine Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Bulbul\u2010Baskan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Uludag University School of Medicine Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve Hatun","family":"Saricam","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oltu State Hospital Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andac","family":"Salman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Marmara University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahide","family":"Onsun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bezm\u2010i Alem University School of Medicine   Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Sarioz","sequence":"additional","affiliation":[{"name":"Department of Public Health Marmara University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMPed.S8045"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02753.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2010.07507_supp.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066886"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2012.12.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4274\/turkderm.45.s22"},{"key":"e_1_2_7_8_1","first-page":"e34","article-title":"Drug survival studies in dermatology: principles, purposes, and pitfalls","volume":"135","author":"Reek JM","year":"2015","journal-title":"J Invest Dermatol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2014.04.004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13343"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10213.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics3010053"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02445.x"},{"issue":"3","key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"doj_21769","DOI":"10.5070\/D3203021769","article-title":"Summary of the Dutch S3\u2010guidelines on the treatment of psoriasis 2011","volume":"20","author":"Zweegers J","year":"2014","journal-title":"Dermatol Online J"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09593.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-011-1587-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12749"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2014.996515"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00629.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1991.tb03934.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.03993.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04644.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.07.043"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.22.2868"},{"key":"e_1_2_7_25_1","unstructured":"European Medicines Agengy[homepage on the internet].Adalimumab. 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