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It usually occurs in middle\u2010aged or older patients, with male predominance, and can involve multiple organs synchronously or metachronously. Patients with IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>generally respond to steroid therapy. IgG4\u2010related skin lesions are typically erythematous and itchy plaques, subcutaneous nodules, or papules like prurigo nodularis located on the head and neck areas. Histologically, lymphoplasmacytic infiltrates with abundant IgG4+ plasma cells are seen in the dermis and\/or subcutaneous tissue. The skin condition of IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>does not necessarily exhibit infiltration of IgG4<jats:sup>+<\/jats:sup>plasma cells, which is a prerequisite for IgG4\u2010related skin disease, but such skin lesions without infiltration by IgG4<jats:sup>+<\/jats:sup>plasma cells can be included in the skin manifestations of IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.13723","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T10:21:39Z","timestamp":1488536499000},"page":"288-296","source":"Crossref","is-referenced-by-count":27,"title":["Immunoglobulin G4\u2010related disease and its skin manifestations"],"prefix":"10.1111","volume":"44","author":[{"given":"Ryoko","family":"Takayama","sequence":"first","affiliation":[{"name":"Department of Dermatology Graduate School of Medicine Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medicine Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehisa","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medicine Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.03.020"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.196"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-011-0508-6"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.72"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204907"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.01.013"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.6.6.545"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02285209"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441005"},{"key":"e_1_2_13_11_1","first-page":"471","article-title":"A clinicopathologic study of Mikulicz's disease","volume":"29","author":"Morgan WS","year":"1953","journal-title":"Am J Pathol"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13296"},{"key":"e_1_2_13_13_1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.0954-6820.1948.tb10081.x","article-title":"Keratoconjunctivitis sicca and chronic polyarthritis","volume":"30","author":"Sjogren H","year":"1948","journal-title":"Acta Med Scand"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740410006439"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-006-0518-Y"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39132"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPTMWTCN04GSJH"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-011-0571-z"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.03.011"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-012-0786-7"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182433d77"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.191"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1990.tb05339.x"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2011.03.006"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205233"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.034"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.327125032"},{"key":"e_1_2_13_28_1","first-page":"297","article-title":"Usefulness of PET\/CT imaging in systemic IgG4\u2010related sclerosing disease. 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