{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T06:26:32Z","timestamp":1749018392082},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T00:00:00Z","timestamp":1482796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous leiomyomas are benign smooth muscle tumors that are occasionally painful. The mechanism of pain related to leiomyoma is not fully understood. To investigate the possible involvement of algoneic factors in pain from cutaneous leiomyomas. We present a case of cutaneous leiomyoma with severe, diffused pain in a large area and collected 10 more specimens of cutaneous leiomyoma with or without pain in patient histories. We immunohistochemiacally examined the expression of algoneic factors: serotonin, histamin, Substance P, <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">BDKRB<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">VR<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>. We compared the pain area and expression of algoneic factors to reveal possible correlations. We describe here a patient with a cutaneous leiomyoma 1\u2010cm in diameter, which caused severe pain diffused throughout an area of 20\u2010cm around the tumor. The pain completely resolved after surgical excision of the leiomyoma. We observed that the leiomyoma cells expressed <jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PGE<\/jats:styled-content>2 and <jats:styled-content style=\"fixed-case\">VR<\/jats:styled-content>1 in this case. We found a positive correlation between <jats:styled-content style=\"fixed-case\">VR<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>2 expression in the leiomyoma cells and areas with pain around the tumors among 11 specimens in total. <jats:styled-content style=\"fixed-case\">VR<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>2 might be key algogenic substances in painful leiomyoma.<\/jats:p>","DOI":"10.1111\/1346-8138.13726","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T11:27:01Z","timestamp":1482838021000},"page":"690-694","source":"Crossref","is-referenced-by-count":1,"title":["Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas"],"prefix":"10.1111","volume":"44","author":[{"given":"Yoshiko","family":"Kagimoto","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenshi","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoko","family":"Shimada\u2010Ohmori","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukikazu","family":"Numata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuya","family":"Aiba","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.107970"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000173695"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.2.199"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.121358"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.3.1438"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00372.2010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06514.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-11-70"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.11.6155"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04082.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.487"},{"key":"e_1_2_6_14_1","first-page":"53.40","volume-title":"Rook's Textbook of Dermatology","author":"Calonje E","year":"2004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840701)54:1<126::AID-CNCR2820540125>3.0.CO;2-F"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/smns.1995.0025"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.042307.110802"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00828-W"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.67.915"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00394-8"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13726","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:13:57Z","timestamp":1695471237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,27]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/1346-8138.13726"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13726","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,27]]}}}