{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:01:37Z","timestamp":1762272097547},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T00:00:00Z","timestamp":1484870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Applying Health Technology","award":["H24-applying-general-006"],"award-info":[{"award-number":["H24-applying-general-006"]}]},{"name":"Ministry of Health, Labor and Welfare, Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cancer\u2013testis antigens (CTA) are a large family of tumor\u2010associated antigens expressed by a variety of cancer cells and primitive germ cells of the adult testis and placenta. These tumor\u2010restricted expressing patterns suggest that CTA would be ideal targets for tumor\u2010specific immunotherapy. XAGE\u20101 is a CTA that was originally identified by computer\u2010based screening, and four transcription variants, XAGE\u20101a, \u20101b, \u20101c and \u20101d, have been characterized to date. Although the presence of XAGE\u20101 transcripts has been reported in various cancers, the expression of XAGE\u20101b in melanoma has not been fully characterized. In this study, we performed immunohistochemical staining of XAGE\u20101b together with NY\u2010ESO\u20101, a well\u2010known CTA, in 113 melanoma samples obtained from 84 patients and evaluated their expression in tumor cells. The effects of expression on tumor progression and patient prognosis were analyzed. Both XAGE\u20101b and NY\u2010ESO\u20101 were expressed at high levels in lymph node metastasis and skin metastasis samples compared with the primary site (<jats:italic>P<\/jats:italic> &lt; 0.01 in XAGE\u20101b and <jats:italic>P<\/jats:italic> &lt; 0.05 in NY\u2010ESO\u20101). In a subgroup analysis of 22 patients with stage III lymph node metastasis, overall survival was significantly higher in the XAGE\u20101b and NY\u2010ESO\u20101 double\u2010negative group than in the other groups (<jats:italic>P<\/jats:italic> &lt; 0.05). These results suggest that lack of XAGE\u20101b and NY\u2010ESO\u20101 expression could have a positive influence on clinical outcome in patients with melanoma.<\/jats:p>","DOI":"10.1111\/1346-8138.13730","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T15:54:39Z","timestamp":1484927679000},"page":"671-680","source":"Crossref","is-referenced-by-count":8,"title":["Lack of XAGE\u20101b and NY\u2010ESO\u20101 in metastatic lymph nodes may predict the potential survival of stage III melanoma patients"],"prefix":"10.1111","volume":"44","author":[{"given":"Mariko","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Dermatology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeru","family":"Funakoshi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Kameyama","sequence":"additional","affiliation":[{"name":"Department of Pathology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Division of Cellular Signaling Institute for Advanced Medical Research Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Medical Science (Medical Research Center) Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Faculty of Health and Welfare Kawasaki University of Medical Welfare Kurashiki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Amagai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Tanese","sequence":"additional","affiliation":[{"name":"Department of Dermatology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3239"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412082"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0013-0"},{"key":"e_1_2_7_5_1","first-page":"1493","article-title":"New developments in the treatment of metastatic melanoma: immune checkpoint inhibitors and targeted 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