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In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work\u2010up. In light of this, it is important to be aware of the various entities that have been reported to exhibit granular cell morphology. In this review such tumors are discussed along with pertinent clinical and histopathological features.<\/jats:p>","DOI":"10.1111\/1346-8138.13758","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T10:21:39Z","timestamp":1488536499000},"page":"251-258","source":"Crossref","is-referenced-by-count":29,"title":["Granular cell differentiation: A review of the published work"],"prefix":"10.1111","volume":"44","author":[{"given":"Michael A.","family":"Cardis","sequence":"first","affiliation":[{"name":"MedStar Washington Hospital Center\/MedStar Georgetown University Hospital Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Ni","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jag","family":"Bhawan","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12250"},{"key":"e_1_2_7_3_1","volume-title":"McKee's Pathology of the Skin: With Clinical Correlations","author":"Calonje E","year":"2012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1976.tb00841.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199101000-00006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445479"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-199907000-00002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00632.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01374.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01391.x"},{"key":"e_1_2_7_11_1","first-page":"34","article-title":"Granular cell variant of atypical fibroxanthoma. 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