{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:50:54Z","timestamp":1792029054790,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thymoma\u2010associated multi\u2010organ autoimmunity disease (TAMA) is a rare paraneoplastic disorder, clinicopathologically similar to graft\u2010versus\u2010host disease (GVHD). Many reported cases follow a difficult course; half of them die from serious infectious diseases subsequent to immunosuppression induced by chemotherapy for unresectable thymoma, or intensive therapies including systemic steroids for complicating autoimmune diseases and GVHD\u2010like symptoms. We report a patient whose skin symptoms were improved subsequently to total thymectomy. The patient also presented with hypogammaglobulinemia, which led to the diagnosis of complicated Good syndrome. Taking account of her immunodeficient condition, antibiotics and i.v. immunoglobulin were administrated promptly on onset of bacterial pneumonia, which was successfully treated. According to a review of the published work, treatments with systemic steroids for skin symptoms have limited effects and may contribute to serious infection. Our case indicates that successful treatment of thymoma itself may lead to the amelioration of the disease. The management priority should be given to the treatment of thymoma and the control of subsequent immune abnormality other than GVHD\u2010like erythroderma.<\/jats:p>","DOI":"10.1111\/1346-8138.13777","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T10:32:56Z","timestamp":1488537176000},"page":"830-835","source":"Crossref","is-referenced-by-count":25,"title":["Thymoma\u2010associated multi\u2010organ autoimmunity: A case of graft\u2010versus\u2010host disease\u2010like erythroderma complicated by Good syndrome successfully treated by thymectomy"],"prefix":"10.1111","volume":"44","author":[{"given":"Ayano","family":"Fukushima","sequence":"first","affiliation":[{"name":"Department of Dermatology Hiratsuka City Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Ichimura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hiratsuka City Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Obata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hiratsuka City Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misaki","family":"Kinoshita\u2010Ise","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hiratsuka City Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Fujio","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hiratsuka City Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Takeno","sequence":"additional","affiliation":[{"name":"Department of Allergy and Rheumatology Nippon Medical School Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Konohana","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hiratsuka City Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.02.027"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.10.080"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12642"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199502000-00011"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750023660"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000059130.68845.2c"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.03.2011.3936"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2007.08.010"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04472.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ269"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13777","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:36:38Z","timestamp":1695573398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,3]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/1346-8138.13777"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13777","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,3]]}}}