{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:57:04Z","timestamp":1793059024525,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T00:00:00Z","timestamp":1489190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Skin lesions in sarcoidosis are often the initial symptoms that enable the dermatologist to be the first to diagnose this granulomatosis. However, diagnosis is sometimes very problematic. In 2015, the diagnostic criteria for sarcoidosis were updated in Japan, with elevated serum soluble interleukin\u20102 receptor (<jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20102R) replacing negative tuberculin reaction. Therefore, we assessed the clinical utility of <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20102R compared with two other common markers, angiotensin\u2010converting enzyme (<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>) and lysozyme, in patients who visited the dermatology clinic. Data from 72 patients showed that <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20102R was more sensitive than both <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> and lysozyme in supporting a diagnosis of sarcoidosis (52.8%) compared with <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> (29%) and lysozyme (26.4%). Additionally, the <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20102R level was significantly higher in patients with multiple organ involvement and parenchymal infiltration. Patients with elevated <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20102R levels had higher serum <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> and lysozyme levels, a higher incidence of pulmonary involvement, more severe chest radiographic stage and a high incidence of expression\u2010specific signs by imaging analysis. Receiver\u2013operator curve analysis showed that <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20102R was a better marker at the threshold cut\u2010off point compared with <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> and lysozyme for identifying patients with multiple organ involvement, detecting patients with pulmonary disease and parenchymal infiltration as well as predicting the presence of specific signs in the diagnosis of sarcoidosis. Moreover, the kinetics of <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20102R levels correlated closely with clinical manifestations, in contrast to the modest changes of <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> and lysozyme levels during the follow\u2010up period. In conclusion, <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20102R may be considered a good marker for diagnosis and a potential indicator of disease activity.<\/jats:p>","DOI":"10.1111\/1346-8138.13792","type":"journal-article","created":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T08:39:24Z","timestamp":1489221564000},"page":"789-797","source":"Crossref","is-referenced-by-count":73,"title":["Serum soluble interleukin\u20102 receptor level is more sensitive than angiotensin\u2010converting enzyme or lysozyme for diagnosis of sarcoidosis and may be a marker of multiple organ involvement"],"prefix":"10.1111","volume":"44","author":[{"given":"Chuyen","family":"Thi Hong Nguyen","sequence":"first","affiliation":[{"name":"Department of Dermatology Kansai Medical University Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotomo","family":"Kambe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kansai 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