{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:15:56Z","timestamp":1785575756910,"version":"3.56.0"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T00:00:00Z","timestamp":1490140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["26461663"],"award-info":[{"award-number":["26461663"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Gibberellin\u2010regulated protein (<jats:styled-content style=\"fixed-case\">GRP<\/jats:styled-content>) is a new allergen in peach allergy, with an amino acid sequence very well conserved through several botanical species. We investigated the allergenicity of <jats:styled-content style=\"fixed-case\">GRP<\/jats:styled-content> in fruit allergies other than peaches and identified the clinical characteristics of fruit allergy patients with <jats:styled-content style=\"fixed-case\">GRP<\/jats:styled-content> sensitization. One hundred consecutive Japanese patients with fruit allergies were enrolled in the present study. To identify the features of <jats:styled-content style=\"fixed-case\">GRP<\/jats:styled-content> sensitization, we selected patients with negative Immuno<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> results for Bet v 1 homologs and profilin, which are marker allergens for pollen\u2010food allergy syndrome (<jats:styled-content style=\"fixed-case\">PFAS<\/jats:styled-content>), or lipid transfer protein. These patients underwent specific immunoglobulin E measurements by enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>) and skin prick tests (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) using purified <jats:styled-content style=\"fixed-case\">nP<\/jats:styled-content>ru p 7. Twenty of 100 consecutive patients with fruit allergies had negative Immuno<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> results for Bet v 1 homologs and profilin. Thirteen (65.0%) of the 20 patients had positive <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> results using <jats:styled-content style=\"fixed-case\">nP<\/jats:styled-content>ru p 7, whereas one of the 20 patients had positive Immuno<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> results for Pru p 3. In 13 <jats:styled-content style=\"fixed-case\">nP<\/jats:styled-content>ru p 7\u2010sensitized patients, the causative foods were peaches (92.3%), apricots (61.5%), oranges (46.2%) and apples (30.8%). Ten patients (76.9%) had multiple causative fruits. Frequent symptoms included facial edema (92.3%) and laryngeal tightness (66.7%). In eight patients (61.5%), exercise or aspirin intake enhanced the allergic reaction onset as cofactors. The prevalence of <jats:styled-content style=\"fixed-case\">GRP<\/jats:styled-content> sensitization was high in Japanese fruit allergy patients except for <jats:styled-content style=\"fixed-case\">PFAS<\/jats:styled-content> patients. In conclusion, <jats:styled-content style=\"fixed-case\">GRP<\/jats:styled-content>\u2010sensitized patients may have allergies to multiple fruits and may show peculiar characteristics such as facial swelling and cofactor dependence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1346-8138.13795","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T05:21:47Z","timestamp":1490246507000},"page":"735-741","source":"Crossref","is-referenced-by-count":41,"title":["High prevalence of sensitization to gibberellin\u2010regulated protein (peamaclein) in fruit allergies with negative immunoglobulin E reactivity to Bet v 1 homologs and profilin: Clinical pattern, causative fruits and cofactor effect of gibberellin\u2010regulated protein allergy"],"prefix":"10.1111","volume":"44","author":[{"given":"Naoko","family":"Inomata","sequence":"first","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Miyakawa","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Aihara","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12028"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.11.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000375469"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32814a5401"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.04071.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13316"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1989.tb02707.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250443"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.010685"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(03)02006-2"},{"key":"e_1_2_7_12_1","first-page":"351","article-title":"PT with heat\u2010processed apple peel extract to detect LTP hypersensitivity","volume":"38","author":"Asero R","year":"2006","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(03)02016-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-964891"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04601.x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13795","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:36:40Z","timestamp":1695573400000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,22]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/1346-8138.13795"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13795","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,22]]}}}