{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:28:13Z","timestamp":1740144493345,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T00:00:00Z","timestamp":1489190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008273","name":"Novartis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008273","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anhidrosis\/hypohidrosis are conditions presenting various level of sweating dysfunction. Among them, acquired idiopathic generalized anhidrosis (<jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content>) presents inadequate decrease or loss of sweating without apparent neurological and dermatological symptoms except cholinergic urticaria. Recently, serum level of carcinoembryonic antigen (<jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>), one of the most well\u2010known tumor markers, has been proposed as a clinical marker reflecting activity of <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content>. This study was performed to verify the specificity and independence of serum <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> level from the other serum tumor markers especially related to adenocarcinoma. The expression of various tumor markers in the serum collected from three healthy control subjects, four <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content> cases, and a cholinergic urticaria (<jats:styled-content style=\"fixed-case\">CU<\/jats:styled-content>) case with elevation of serum <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> level and history of hyperthermia was analyzed using a membrane\u2010based antibody array. In all <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CU<\/jats:styled-content> cases, the intensity of <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> was significantly increased (7.60\u201315.9 times compared with that of control), relatively well\u2010reflecting the serum <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> level, and the mean intensity of <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> was 11.8 times higher than the control subjects (<jats:italic>P<\/jats:italic> = 0.0011). On the other hand, the ratio of carbohydrate antigen (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>)125 and <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>19\u20109 was 1.93 and 0.23 times compared with the mean intensity of the control subjects, respectively, and there was no statistical significance. Immunohistochemistry on 10 <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content> cases showed increased expression of <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> but not <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>19\u20109 and <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>125 in the eccrine sweat glands. In conclusion, the elevation of serum <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> level was independent from the other tumor markers in hypohidrotic condition represented by <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.13828","type":"journal-article","created":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T08:38:45Z","timestamp":1489221525000},"page":"903-908","source":"Crossref","is-referenced-by-count":2,"title":["Serum carcinoembryonic antigen specifically increases among various serum markers of adenocarcinoma in hypohidrosis or conditions related to hypohidrosis"],"prefix":"10.1111","volume":"44","author":[{"given":"Masaru","family":"Honma","sequence":"first","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa 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