{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:28:30Z","timestamp":1789079310612,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T00:00:00Z","timestamp":1489190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K 10274"],"award-info":[{"award-number":["16K 10274"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with extramammary Paget's disease (<jats:styled-content style=\"fixed-case\">EMPD<\/jats:styled-content>) have a relatively good prognosis, when spread of the tumor cells is limited to the epidermis. However, invasive <jats:styled-content style=\"fixed-case\">EMPD<\/jats:styled-content> has a poor prognosis, when the patients have regional lymph node metastasis. Detection of nodal metastasis is thus mandatory to manage <jats:styled-content style=\"fixed-case\">EMPD<\/jats:styled-content>. To evaluate the <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography (<jats:styled-content style=\"fixed-case\">FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>) imaging to assess lymph node metastasis, 15 patients with histologically proven primary <jats:styled-content style=\"fixed-case\">EMPD<\/jats:styled-content> were enrolled in this study. All patients underwent whole\u2010body <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> prior to sentinel lymph node biopsy (<jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content>). The maximum standardized uptake value (<jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>max) of more than 2.5 was evaluated as positive <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> indicative of malignancy. Among 14 cases with the primary genital lesions, 11 cases underwent bilateral <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content> of the inguinal nodal basin and the remaining three cases unilateral <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content>. One case with a primary axillary lesion underwent unilateral <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content> of the axillary nodal basin. Therefore, a total of 26 regional basins were investigated. In general, nodal basins can be categorized into four groups: (i) histologically negative and <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> negative (true negative); (ii) histologically positive and <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> negative (false negative); (iii) histologically positive and <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> positive (true positive); and (iv) histologically negative and <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> positive (false positive) groups. In the 26 nodal basins, there were 19 true negative and seven true positive cases, and neither false negative nor false positive cases were observed. The mean <jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>max was significantly higher in the true positive basins (8.03\u00a0\u00b1\u00a03.34) than in the true negative basins (0.26\u00a0\u00b1\u00a00.56). The <jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>max value may be useful for detection of nodal metastasis.<\/jats:p>","DOI":"10.1111\/1346-8138.13833","type":"journal-article","created":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T08:42:15Z","timestamp":1489221735000},"page":"939-943","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of positron emission tomography imaging to detect lymph node metastases in patients with extramammary Paget's disease"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6459-0626","authenticated-orcid":false,"given":"Masao","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu 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